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dc.contributor.authorAbildgaard, Anders
dc.contributor.authorWegener, Gregers
dc.contributor.authorElfving, Betina
dc.contributor.authorHokland, Marianne
dc.contributor.authorLund, Sten
dc.identifier.citationAbildgaard, A. et al. 2018. The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour. Archives of physiology and biochemistry, 124(4):306-312. []en_US
dc.identifier.issn1744-4160 (Online)
dc.description.abstractContext: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA). Objective: We therefore wanted to study the isolated effect of IPA on behaviour and glucose metabolism in rats. Methods: Male Sprague–Dawley rats were fed control or IPA-enriched diet for six weeks (n = 12 per group) and assessed in the elevated plus maze, open field and forced swim test. Blood glucose, metabolic hormones and the white blood cell (WBC) composition were analysed. Results: IPA (mean intake 27.3 mg/kg/day) significantly lowered fasting blood glucose level by 0.42 mM (95% CI 0.11–0.73). Similarly, fasting plasma insulin levels and the homeostatic model assessment (HOMA) index of insulin resistance were reduced, whereas plasma metabolic hormones, behaviour and WBC composition remained unaffected by IPA. Conclusions: Our findings highlight IPA as a promising candidate for treatment of metabolic disorders associated with insulin resistanceen_US
dc.publisherTaylor & Francisen_US
dc.subjectBlood glucoseen_US
dc.subjectDiabetes mellitusen_US
dc.titleThe microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviouren_US
dc.contributor.researchID22353003 - Wegener, Gregers

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