• Login
    View Item 
    •   NWU-IR Home
    • Research Output
    • Faculty of Health Sciences
    • View Item
    •   NWU-IR Home
    • Research Output
    • Faculty of Health Sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Defensive coping facilitated a smaller cortisol-to-estradiol ratio and a higher hypertension risk: the SABPA study

    Thumbnail
    Date
    2018
    Author
    Malan, Leoné
    De Kock, Andrea
    Hamer, Mark
    Cockeran, Marike
    Malan, Nicolaas Theodor
    Metadata
    Show full item record
    Abstract
    Objectives: Taxing psychosocial stress and defensive coping have been associated with hypoactivity in cortisol, a vasoconstrictive agent. Estradiol has vasodilatory properties with cardio- and neuroprotective effects. It can however also induce α1-adrenergic vasoconstrictive responsiveness. We aimed to determine whether the cortisol-to-estradiol ratio (Cort:E2) may augment α1-adrenergic responsiveness and hypertension risk when habitually using defensive coping. Methods: African (n = 168) and Caucasian (n = 207) men and women (46 ± 9 years) were included. Preferential use of defensive coping was determined from Coping Strategy Indicator questionnaire scores. 24h Ambulatory blood pressure was obtained. Fasting serum estradiol and cortisol samples were collected before 09h00 and Cort:E2 was calculated. Results: Estradiol was higher in ethnic-coping groups. Smaller Cort:E2, higher estradiol levels, self-reported emotional stress (19.05% vs. 9.66%) and 24h blood pressure reaching hypertensive status (65% vs. 24%) were evident in African compared to Caucasian men (p ≤ .05). A smaller Cort:E2 was associated with augmented 24h SBP and 24h DBP in African men [Adj R2 0.21–0.29 (p ≤ .05)], and especially when utilizing defensive coping [Adj R2 0.34–0.38 (p ≤ .001)]. Conclusions: A smaller Cort:E2 was associated with raised blood pressure in defensive coping African men. Defensive coping, possibly via highly activated α1-adrenergic vasoconstrictive responses, may facilitate neuro-endocrine dysfunction and hypertension in African men
    URI
    http://hdl.handle.net/10394/31949
    https://www.tandfonline.com/doi/full/10.1080/08037051.2018.1461011
    https://doi.org/10.1080/08037051.2018.1461011
    Collections
    • Faculty of Health Sciences [2368]
    • Faculty of Natural and Agricultural Sciences [4789]

    Copyright © North-West University
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of NWU-IR Communities & CollectionsBy Issue DateAuthorsTitlesSubjectsAdvisor/SupervisorThesis TypeThis CollectionBy Issue DateAuthorsTitlesSubjectsAdvisor/SupervisorThesis Type

    My Account

    LoginRegister

    Copyright © North-West University
    Contact Us | Send Feedback
    Theme by 
    Atmire NV