The oxidative stress profile and its relation to vascular function in a bi-ethnic cohort: the SABPA study
Date
2019Author
Huisman, Hugo
Mels, Catharina
Kruger, Ruan
Smith, Wayne
Du Plooy, Christine
Metadata
Show full item recordAbstract
Oxidative stress and inflammation
has been implicated in arterial stiffness, and hypertension development. Oxidative stress may interfere with normal vascular function by inactivation of NO and/or the production of endothelin-1.
Limited information exists regarding the link of NO and endothelin-1 with oxidative stress markers in black South Africans, a population known for early vascular compromise and increasing prevalence of hypertension. Our objective was to compare variables
implicated in vascular function namely NO metabolites, endothelium-1 and markers of inflammation and oxidative stress in a biethnic South African population. We also investigated the association of endothelin-1 with markers of oxidative stress implicated in
arterial stiffness and endothelial function as well as if an increase
in endothelin-1 levels over time predict a change in markers implicated in vascular function