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    Brain-derived-neurotrophic-factor, dynamic retinal vessel responses during flicker light and stroke risk: the SABPA study

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    Date
    2019
    Author
    Wentzel, Annemarie
    Malan, Leoné
    Von Känel, Roland
    Smith, Wayne
    Malan, Nicolaas
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    Abstract
    Assessment of the retinal vessels’ structure and function provides an automated and objective approach to noninvasively assess the condition of the cerebral microvasculature and indicates susceptibility for stroke. Neurons, glial cells and the cerebral endothelium exhibit a unique relationship as they function as a cohesive unit namely, neurovascular coupling, similar to that of the retinal microvasculature. Brain-derived neurotrophic factor (BDNF) plays an essential role in the survival, growth and maintenance of neural structures. BDNF is actively released by cerebral endothelial cells, constituting a link between maintaining cerebral and possibly retinal blood flow as well as effective neurovascular coupling
    URI
    http://hdl.handle.net/10394/32362
    https://www.karger.com/Article/Pdf/499516
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    • Conference Papers - Potchefstroom Campus [697]
    • Faculty of Health Sciences [2368]

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