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dc.contributor.authorSmuts, Corneliusen_US
dc.contributor.authorDalton, A
dc.contributor.authorWolmarans, P
dc.contributor.authorWitthuhn, R C
dc.contributor.authorvan Stuijvenberg, M E
dc.contributor.authorSwanevelder, S A
dc.date.accessioned2010-08-04T15:36:06Z
dc.date.available2010-08-04T15:36:06Z
dc.date.issued2009en_US
dc.identifier.citationSMUTS, C., DALTON, A., WOLMARANS, P., WITTHUHN, R.C., VAN STUIJVENBERG, M.E. & SWANEVELDER, S.A. 2009. A randomised control trial in schoolchildrend showed improvement in cognitive function after consuming a bread spread, containing fish flour from a marine source. Prostaglandins Leukotrienes And Essential Fatty Acids, 80(2-3):143-149, Feb.[http://www.sciencedirect.com/science/journal/09523278] [http://www.elsevier.com/wps/find/journaldescription.cws_home/623065/description#description]en_US
dc.identifier.issn0952-3278
dc.identifier.urihttp://hdl.handle.net/10394/3367
dc.description.abstractBackground In humans, n-3 long-chain polyunsaturated fatty acids play a well-documented role in brain development and function. Docosahexaenoic acid and arachidonic acid are major structural components of the brain and a deficiency thereof may bring about changes in the behaviour domains of the brain. Objective This trial investigated the effect of an experimental fish-flour bread spread rich in n-3 long-chain polyunsaturated fatty acids, on cognition of children (7–9 yr). Design Subjects (n=183) were randomly assigned to an experimental (n=91) and control group (n=92), receiving either the fish-flour spread or a placebo spread for 6 months in a single-blind study. Plasma and red blood cell phospholipid fatty acid composition and cognition were measured at baseline and post-intervention. Results After the intervention, eicosapentaenoic and docosahexaenoic acid levels were significantly higher in the experimental group compared to the control group (p< 0.0001). Significant intervention effects were also observed for the Hopkins Verbal Learning Test Recognition (estimated effect size: 0.80; 95% confidence interval (CI): 0.15; 1.45) and Discrimination Index (estimated effect size: 1.10; 95% CI: 0.30; 1.91), as well as the Spelling test (estimated effect size: 2.81; 95% CI: 0.59; 5.02) by both per protocol and intention to treat analyses. A marginally significant (p=0.0646) effect was observed for the Reading test (estimated effect size: 2.21; 95% CI: −0.14; 4.56) only in the per protocol analysis.
dc.description.urihttp://dx.doi.org/10.1016/j.plefa.2008.12.006
dc.publisherElsevier Ltd.
dc.titleA randomised control trial in schoolchildrend showed improvement in cognitive function after consuming a bread spread, containing fish flour from a marine sourceen_US


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