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dc.contributor.authorSchutte, Alettaen_US
dc.contributor.authorFourie, Catharinaen_US
dc.contributor.authorHuisman, Hugoen_US
dc.contributor.authorVan Rooyen, Johannesen_US
dc.contributor.authorMalan, Leoneen_US
dc.contributor.authorMalan, Nicolaasen_US
dc.contributor.authorSchutte, Rudolphen_US
dc.identifier.citationSCHUTTE, A., FOURIE, C., HUISMAN, H., VAN ROOYEN, J., MALAN, L., MALAN, N. & SCHUTTE, R. 2009. The Association of Red Blood Cell Counts with Endothelin-1 in African and Caucasian Women. Clinical And Experimental Hypertension, 31(1):1-10, Feb. []en_US
dc.description.abstractThe literature shows an increase in endothelin-1 with increased levels of erythrocytes. There are also indications that inflammation and elevated endothelin-1 levels interact with erythropoiesis. In this study, the association of erythrocytes and endothelin-1 in women of different ethnicities was investigated. Blood pressure, vascular resistance, and C-reactive protein (P = 0.09) were significantly higher in the African women (n = 102) compared to the Caucasian women (n = 115), while arterial compliance was significantly lower in the African women with no significant differences for endothelin-1. In single, partial, and multiple regression analyses, there was a significant positive correlation between the red blood cell count and log endothelin-1 in the Caucasians while in the Africans there was a weak negative correlation. This is an indication that endothelin-1 might interfere with erythrocyte production in Africans with higher levels of inflammation.
dc.publisherInforma Healthcare
dc.titleThe Association of Red Blood Cell Counts with Endothelin-1 in African and Caucasian Womenen_US

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