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The Association of Red Blood Cell Counts with Endothelin-1 in African and Caucasian Women

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dc.contributor.author Schutte, Aletta en_US
dc.contributor.author Fourie, Catharina en_US
dc.contributor.author Huisman, Hugo en_US
dc.contributor.author Van Rooyen, Johannes en_US
dc.contributor.author Malan, Leone en_US
dc.contributor.author Malan, Nicolaas en_US
dc.contributor.author Schutte, Rudolph en_US
dc.date.accessioned 2010-08-04T15:36:10Z
dc.date.available 2010-08-04T15:36:10Z
dc.date.issued 2009 en_US
dc.identifier.citation SCHUTTE, A., FOURIE, C., HUISMAN, H., VAN ROOYEN, J., MALAN, L., MALAN, N. & SCHUTTE, R. 2009. The Association of Red Blood Cell Counts with Endothelin-1 in African and Caucasian Women. Clinical And Experimental Hypertension, 31(1):1-10, Feb. [http://www.ingentaconnect.com/] en_US
dc.identifier.issn 1064-1963
dc.identifier.uri http://hdl.handle.net/10394/3388
dc.description.abstract The literature shows an increase in endothelin-1 with increased levels of erythrocytes. There are also indications that inflammation and elevated endothelin-1 levels interact with erythropoiesis. In this study, the association of erythrocytes and endothelin-1 in women of different ethnicities was investigated. Blood pressure, vascular resistance, and C-reactive protein (P = 0.09) were significantly higher in the African women (n = 102) compared to the Caucasian women (n = 115), while arterial compliance was significantly lower in the African women with no significant differences for endothelin-1. In single, partial, and multiple regression analyses, there was a significant positive correlation between the red blood cell count and log endothelin-1 in the Caucasians while in the Africans there was a weak negative correlation. This is an indication that endothelin-1 might interfere with erythrocyte production in Africans with higher levels of inflammation.
dc.description.uri http://dx.doi.org/10.1080/10641960802409838
dc.publisher Informa Healthcare
dc.title The Association of Red Blood Cell Counts with Endothelin-1 in African and Caucasian Women en_US


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