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dc.contributor.authorVenter, Christenen_US
dc.contributor.authorNorth, C Jen_US
dc.contributor.authorJerling, Johannen_US
dc.date.accessioned2010-08-04T15:36:11Z
dc.date.available2010-08-04T15:36:11Z
dc.date.issued2009en_US
dc.identifier.citationVenter, C. et al. 2009. The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease. European Journal Of Clinical Nutrition, 63(8):921-933, Feb. [http://www.nature.com/ejcn/index.html]en_US
dc.identifier.issn0954-3007
dc.identifier.issn1476-5640 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/3394
dc.identifier.urihttp://dx.doi.org/10.1038/ejcn.2009.8
dc.description.abstractBackground: C-reactive protein (CRP), a sensitive marker of inflammation, is an independent predictor of future cardiovascular disease (CVD), which is a major cause of death worldwide. In epidemiological trials, high-fibre intakes have consistently been associated with reduction in CVD risk and CRP levels. Objective: The objective of this study was to assess the influence of dietary fibre (DF) on CRP in clinical trials. Data sources: Databases were searched from the earliest record to April 2008 and supplemented by crosschecking reference lists of relevant publications. Study selection: Human adult intervention trials, at least 2 weeks in duration, with an increased and measurable consumption of DF were included and rated for quality. Data synthesis: Seven clinical trials were included, and six of these reported significantly lower CRP concentrations of 25–54% with increased DF consumption with dosages ranging between 3.3–7.8 g/MJ. The seventh trial with psyllium fibre supplementation failed to lower CRP levels significantly in overweight/obese individuals. Weight loss and altered fatty acid intakes were present in most of the studies. Conclusions: In the presence of weight loss and modified saturated, monounsaturated and polyunsaturated fat intakes, significantly lower CRP concentrations (↓25–54%) are seen with increased fibre consumption ( 3.3 g/MJ). Mechanisms are inconclusive but may involve the effect of DF on weight loss, and/or changes in the secretion, turnover or metabolism of insulin, glucose, adiponectin, interleukin-6, free fatty acids and triglycerides. Clinical studies of high- and low-fibre diets are needed to explore the potential favourable effects as observed epidemiologically, and to understand individual susceptibility to its anti-inflammatory effect and long-term cardiovascular reduction.
dc.publisherNature Publishing Group
dc.titleThe effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular diseaseen_US
dc.contributor.researchID10075410 - Jerling, Johann Carl


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