dc.contributor.author | Venter, Christen | en_US |
dc.contributor.author | North, C J | en_US |
dc.contributor.author | Jerling, Johann | en_US |
dc.date.accessioned | 2010-08-04T15:36:11Z | |
dc.date.available | 2010-08-04T15:36:11Z | |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Venter, C. et al. 2009. The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease. European Journal Of Clinical Nutrition, 63(8):921-933, Feb. [http://www.nature.com/ejcn/index.html] | en_US |
dc.identifier.issn | 0954-3007 | |
dc.identifier.issn | 1476-5640 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/3394 | |
dc.identifier.uri | http://dx.doi.org/10.1038/ejcn.2009.8 | |
dc.description.abstract | Background: C-reactive protein (CRP), a sensitive marker of inflammation, is an independent predictor of future cardiovascular disease (CVD), which is a major cause of death worldwide. In epidemiological trials, high-fibre intakes have consistently been associated with reduction in CVD risk and CRP levels. Objective: The objective of this study was to assess the influence of dietary fibre (DF) on CRP in clinical trials. Data sources: Databases were searched from the earliest record to April 2008 and supplemented by crosschecking reference lists of relevant publications. Study selection: Human adult intervention trials, at least 2 weeks in duration, with an increased and measurable consumption of DF were included and rated for quality. Data synthesis: Seven clinical trials were included, and six of these reported significantly lower CRP concentrations of 25–54% with increased DF consumption with dosages ranging between 3.3–7.8 g/MJ. The seventh trial with psyllium fibre supplementation failed to lower CRP levels significantly in overweight/obese individuals. Weight loss and altered fatty acid intakes were present in most of the studies. Conclusions: In the presence of weight loss and modified saturated, monounsaturated and polyunsaturated fat intakes, significantly lower CRP concentrations (↓25–54%) are seen with increased fibre consumption ( 3.3 g/MJ). Mechanisms are inconclusive but may involve the effect of DF on weight loss, and/or changes in the secretion, turnover or metabolism of insulin, glucose, adiponectin, interleukin-6, free fatty acids and triglycerides. Clinical studies of high- and low-fibre diets are needed to explore the potential favourable effects as observed epidemiologically, and to understand individual susceptibility to its anti-inflammatory effect and long-term cardiovascular reduction. | |
dc.publisher | Nature Publishing Group | |
dc.title | The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease | en_US |
dc.contributor.researchID | 10075410 - Jerling, Johann Carl | |