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The Finnish Diabetes Risk Score is associated with Insulin Resistance and Progression towards Type-e Diabetes

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dc.contributor.author Schutte, Aletta en_US
dc.date.accessioned 2010-08-04T15:36:11Z
dc.date.available 2010-08-04T15:36:11Z
dc.date.issued 2009 en_US
dc.identifier.citation SCHUTTE, A. 2009. The Finnish Diabetes Risk Score is associated with Insulin Resistance and Progression towards Type-e Diabetes. Journal Of Clinical Endocrinology And Metabolism, 94(3):920-926 [http://jcem.endojournals.org/] en_US
dc.identifier.issn 0021-972X
dc.identifier.issn 1945-7197(Online)
dc.identifier.uri http://hdl.handle.net/10394/3395
dc.description.abstract Objective: The Finnish Diabetes Risk Score (FINDRISC) questionnaire is a practical screening tool to estimate the diabetes risk and the probability of asymptomatic type 2 diabetes. In this study we evaluated the usefulness of the FINDRISC to predict insulin resistance in a population at increased diabetes risk. Design: Data of 771 and 526 participants in a cross-sectional survey (1996) and a cohort study (1997–2000), respectively, were used for the analysis. Data on the FINDRISC and oral glucose tolerance test parameters were available from each participant. The predictive value of the FINDRISC was cross-sectionally evaluated using the area under the curve-receiver operating characteristics method and by correlation analyses. A validation of the cross-sectional results was performed on the prospective data from the cohort study. Results: The FINDRISC was significantly correlated with markers of insulin resistance. The receiver operating characteristics-area under the curve for the prediction of a homeostasis model assessment insulin resistance index of more than five was 0.78 in the cross-sectional survey and 0.74 at baseline of the cohort study. Moreover, the FINDRISC at baseline was significantly associated with disease evolution (P < 0.01), which was defined as the change of glucose tolerance during the 3 yr follow-up. Conclusions: The results indicate that the FINDRISC can be applied to detect insulin resistance in a population at high risk for type 2 diabetes and predict future impairment of glucose tolerance.
dc.description.uri http://dx.doi.org./10.1210/jc.2007-2427
dc.publisher Endocrine Society
dc.title The Finnish Diabetes Risk Score is associated with Insulin Resistance and Progression towards Type-e Diabetes en_US


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