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dc.contributor.authorSteyn, Stephan F.
dc.contributor.authorHarvey, Brian H.
dc.contributor.authorBrink, Christiaan B.
dc.identifier.citationSteyn, S.F. et al. 2020. Pre-pubertal, low-intensity exercise does not require concomitant venlafaxine to induce robust, late-life antidepressant effects in Flinders sensitive line rats. European journal of neuroscience, 52(8):3979-3994. []en_US
dc.identifier.issn1460-9568 (Online)
dc.description.abstractA significant number of adolescents are considered insufficiently active. This is of concern considering the negative association between physical activity and major depressive disorder (MDD). There is a lack of approved pharmacological treatment options in this population partly due to limited information on the risks associated with lasting effects during early life. Therefore, interest in non-pharmacological strategies is gaining popularity with low- to moderate-intensity exercise being especially attractive for its antidepressant-like effects and augmentation properties in combination with antidepressants. Early-life development might present a unique "window of opportunity" to induce long-term beneficial effects in individuals treated with central acting drugs, such as antidepressants. Therefore, we investigated the bio-behavioural effects of pre-pubertal, low-intensity exercise (EXE) and/or venlafaxine (VEN) on depressive-like behaviour in juvenile (postnatal day 35 (PND35)) and young adult (PND60) stress-sensitive Flinders sensitive line (FSL) rats. Interventions were introduced during pre-pubertal development, that is PND21-34, followed by a 26-day washout/sedentary period, when bio-behavioural analyses were performed in the early adulthood group. VEN, alone or in combination with EXE, proved ineffective in inducing any bio-behavioural changes in either age group. EXE did not induce early-life antidepressant-like effects, despite increasing frontal serotonin (5-HT) and noradrenaline (NA) levels. Later in life (PND60), pre-pubertal exercise reduced immobility and increased coping behaviours, together with increased cortical 5-HT levels, despite a significant reduction in locomotor activity. These findings emphasize a strong serotonergic basis to the observed delayed antidepressant effects of EXE later in lifeen_US
dc.subjectJuvenile depressionen_US
dc.subjectAnimal models of depressionen_US
dc.subjectBehavioural pharmacologyen_US
dc.subjectCellular and molecular assaysen_US
dc.subjectNon-pharmacological augmentationen_US
dc.titlePre-pubertal, low-intensity exercise does not require concomitant venlafaxine to induce robust, late-life antidepressant effects in Flinders sensitive line ratsen_US
dc.contributor.researchID20267398 - Steyn, Stephanus Frederik
dc.contributor.researchID11083417 - Harvey, Brian Herbert
dc.contributor.researchID10073892 - Brink, Christiaan Beyers

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