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dc.contributor.authorDe Brouwer, Geoffrey
dc.contributor.authorFick, Arina
dc.contributor.authorLombaard, Ané
dc.contributor.authorHarvey, Brian H.
dc.contributor.authorWolmarans, De Wet
dc.date.accessioned2020-07-23T07:36:57Z
dc.date.available2020-07-23T07:36:57Z
dc.date.issued2020
dc.identifier.citationDe Brouwer, G. et al. 2020. Large nest building and high marble-burying: two compulsive-like phenotypes expressed by deer mice (Peromyscus maniculatus bairdii) and their unique response to serotoninergic and dopamine modulating intervention. Behavioural brain research, 393: #112794. [https://doi.org/10.1016/j.bbr.2020.112794]en_US
dc.identifier.issn0166-4328
dc.identifier.urihttp://hdl.handle.net/10394/35279
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0166432820304939
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2020.112794
dc.description.abstractThis study aimed to further dissect the deer mouse (Peromyscus maniculatus bairdii) model of compulsive-like behavior with respect to two persistent-like behavioral phenotypes viz. large nest building (LNB) and high marble-burying (HMB), which may be relevant to understanding the neurobiology of different symptom dimensions in obsessive-compulsive and related disorders. Since LNB is sensitive to chronic, high dose escitalopram intervention but HMB is not, we assessed whether the two behaviors could be further distinguished based on their response to 4 weeks of uninterrupted serotoninergic intervention (i.e. escitalopram; ESC; 50 mg/kg/day), dopaminergic antagonism, i.e. flupentixol; FLU; 0.9 mg/kg/day), dopaminergic potentiation (i.e. rasagiline; RAS; 5 mg/kg/day), and their respective combinations with escitalopram (ESC/FLU and ESC/RAS). Here we show LNB to be equally responsive to chronic ESC and ESC/FLU. HMB was insensitive to either of these interventions but was responsive to ESC/RAS. Additionally, we report that scoring preoccupied interaction with marbles over several trials is an appropriate measure of compulsive-like behavioral persistence in addition to the standard marble burying test. Taken together, these data provide further evidence that LNB and HMB in deer mice have distinctive neurobiological underpinnings. Thus, the naturally occurring compulsive-like behaviors expressed by deer mice may be useful in providing a platform to test unique treatment targets for different symptom dimensions of OCD and related disordersen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectOCRDsen_US
dc.subjectMarble-burying testen_US
dc.subjectNest buildingen_US
dc.subjectEscitalopramen_US
dc.subjectDeer mouse modelen_US
dc.titleLarge nest building and high marble-burying: two compulsive-like phenotypes expressed by deer mice (Peromyscus maniculatus bairdii) and their unique response to serotoninergic and dopamine modulating interventionen_US
dc.typeArticleen_US
dc.contributor.researchID11083417 - Harvey, Brian Herbert
dc.contributor.researchID12324515 - Wolmarans, Petrus De Wet
dc.contributor.researchID23511990 - De Brouwer, Geoffrey
dc.contributor.researchID25087657 - Lombaard, Ané


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