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dc.contributor.authorAucamp, Janine
dc.contributor.authorZuma, Nonkululeko H.
dc.contributor.authorN'Da, David D.
dc.date.accessioned2020-10-15T12:05:17Z
dc.date.available2020-10-15T12:05:17Z
dc.date.issued2020
dc.identifier.citationAucamp, J. et al. 2020. In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes. Bioorganic and medicinal chemistry letters, 30(22):Art. #127581. [https://doi.org/10.1016/j.bmcl.2020.127581]en_US
dc.identifier.issn0960-894X
dc.identifier.urihttp://hdl.handle.net/10394/35967
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0960894X20306922
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2020.127581
dc.description.abstractLeishmaniasis is a neglected tropical disease affecting thousands worldwide, especially in developing countries where it co-exists with malaria. Only a handful of drugs are clinically available to treat the disease, but significant limitations threaten their very use. New, safe and effective drugs, including those against malaria-leishmaniasis co-infections, are thus imperative. We assessed the in vitro anti-infective potential of previously synthesized, potent antimalarial artemisinin derivatives. Analogue esters featuring 1,1′-biphenyl and thiophenyl moieties were as much as 30-fold more potent than clinical artemisinins against L. donovani parasites, qualifying them as antipromastigote hits for further investigation in the search for malaria-leishmaniasis co-infection therapiesen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectLeishmaniasisen_US
dc.subjectMalariaen_US
dc.subjectCo-infectionen_US
dc.subjectArtemisininsen_US
dc.subjectAnalogueen_US
dc.subjectHybriden_US
dc.titleIn vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotesen_US
dc.typeArticleen_US
dc.contributor.researchID20505698 - Aucamp, Janine
dc.contributor.researchID23978538 - Zuma, Nonkululeko Hazel
dc.contributor.researchID20883072 - N'Da, David Dago


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