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dc.contributor.authorSchutte, Aletta Elisabethen_US
dc.contributor.authorHuisman, Hugo Willemen_US
dc.contributor.authorSchutte, Rudolphen_US
dc.contributor.authorVan Rooyen, Johannes Marthinusen_US
dc.contributor.authorMalan, Leonéen_US
dc.contributor.authorFourie, Catharina Maria Theresiaen_US
dc.contributor.authorMalan, Nicolaas Theodoren_US
dc.identifier.citationSchutte, A.E. et al. 2010. Adipokines and cardiometabolic function: how are they interlinked? Regulatory peptides, 164(2-3):133-138. []en_US
dc.description.abstractObjective Adipokines contribute directly to the coexistence of insulin resistance and endothelial dysfunction. Most studies focus on a single adipokine. We therefore investigated the independent relationships of leptin, adiponectin, tumor necrosis factor-α, resistin and visfatin, as well as the gut hormone ghrelin with blood pressure and insulin resistance. Secondly we evaluated the interrelationships of adipokines and ghrelin in concert with various cardiometabolic markers. Methods and Results Caucasian women (N = 115) with varying levels of obesity (aged 31.3 ± 9.18 years) were included. Significant correlations of leptin, adiponectin, ghrelin and visfatin with mean arterial pressure (p < 0.05) disappeared after adjustment for age, body mass index and waist circumference. But significant correlations with insulin resistance (HOMA) (for leptin, adiponectin and ghrelin) remained significant after adjustments. Factor analyses yielded five factors, but two main clusters, namely a metabolic syndrome cluster (including leptin, adiponectin and ghrelin) and a vascular atherosclerotic cluster (including tumor necrosis factor-α, visfatin and resistin). Conclusion Factor analyses identified patterns which indicate specific roles of the various adipokines. Leptin, adiponectin and ghrelin were more closely related to insulin resistance and central obesity as core components of the metabolic syndrome. Visfatin, tumor necrosis factor-α and resistin seem to direct their effects onto the vascular system possibly by means of mechanisms such as inflammation, vasoconstriction and coagulation
dc.subjectTumor necrosis factor-α
dc.titleAdipokines and cardiometabolic function: how are they interlinked?en_US
dc.contributor.researchID10062491 - Fourie, Catharina Maria Theresia
dc.contributor.researchID10059539 - Van Rooyen, Johannes Marthinus
dc.contributor.researchID12201405 - Schutte, Rudolph
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID10062718 - Huisman, Hugo Willem
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID10060871 - Malan, Leoné

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