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dc.contributor.authorLombard, Marli C.en_US
dc.contributor.authorN'Da, David D.en_US
dc.contributor.authorBreytenbach, Jaco C.en_US
dc.contributor.authorSmith, Peter J.en_US
dc.contributor.authorLategan, Carmen A.
dc.date.accessioned2012-02-29T09:49:47Z
dc.date.available2012-02-29T09:49:47Z
dc.date.issued2010en_US
dc.identifier.citationLombard, M.C. et al. 2010. Artemisinin quinoline hybrid-dimers: synthesis and in vitro antiplasmodial activity. Bioorganic & medicinal chemistry letters, 20(23):6975-697. [https://doi.org/10.1016/j.bmcl.2010.09.130]en_US
dc.identifier.issn0960-894Xen_US
dc.identifier.issn0968-0896 (Online)en_US
dc.identifier.urihttp://hdl.handle.net/10394/5974
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2010.09.130
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0960894X10014393
dc.description.abstractNovel artemisinin–quinoline hybrid-dimers were synthesized from dihydroartemisinin and different aminoquinolines at elevated temperatures (90–110 °C). All compounds were obtained as the β-isomers and were tested against both chloroquine sensitive and resistant strains of Plasmodium falciparum. Hybrid-dimer 8 showed the highest antiplasmodial activity, inheriting the optimum chain length of three carbon atoms
dc.languageen
dc.publisherElsevieren_US
dc.subjectMalaria
dc.subjectDihydroartemisinin
dc.subjectQuinoline
dc.subjectHybrid
dc.subjectDimer
dc.titleArtemisinin quinoline hybrid-dimers: synthesis and in vitro antiplasmodial activityen_US
dc.contributor.researchID20883072 - N'Da, David Dago
dc.contributor.researchID10059768 - Breytenbach, Jaco Cornelius


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