Show simple item record

dc.contributor.authorN'Da, David D.en_US
dc.contributor.authorBreytenbach, Jaco C.en_US
dc.contributor.authorSmith, Peter J.en_US
dc.contributor.authorLategan, Carmenen_US
dc.date.accessioned2012-02-29T09:49:51Z
dc.date.available2012-02-29T09:49:51Z
dc.date.issued2010en_US
dc.identifier.citationN'Da, D.D. et al. 2010. Synthesis, cytotoxicity and antimalarial activity of ferrocenyl amides of 4-aminoquinolines. Arzneimittelforschung / Drug research, 60(10):627-635. [http://dx.doi.org/10.1055/s-0031-1296337]en_US
dc.identifier.issn0004-4172en_US
dc.identifier.issn1616-7066 (Online)en_US
dc.identifier.urihttp://hdl.handle.net/10394/6006
dc.identifier.urihttp://dx.doi.org/10.1055/s-0031-1296337
dc.identifier.urihttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0031-1296337
dc.description.abstractSeries of 4-aminoquinolines bearing an amino side chain linked to the ferrocene moiety through an amide bond were synthesized and evaluated for their antimalarial activity against both chloro-quine-sensitive (D10, CQ-S) and chloro-quine-resistant (Dd2, CQ-R) strains of Plasmodium falciparum. They were also tested for cytotoxicity against Chinese Hamster Ovarian (CHO) cells. Amide 12 featuring propyl side chain linked to the ferrocene ring was the most active of all tested compounds. With an IC50 value of 0.08 µg/mL, this amide showed 1.5-fold higher activity than chloroquine diphosphate (IC50 = 0.12 µg/mL) against the resistant strain, with a selectivity index of 550 indicating its high selectivity towards the parasite. Derivatives which were equipotent against both strains also showed up to ten-fold increase in activity compared to primaquine
dc.description.urihttp://dx.doi.org/10.1002/chin.201108189en_US
dc.languageen
dc.publisherThiemeen_US
dc.subject4-Aminoquinolines
dc.subjectAntimalarial activity
dc.subjectCytotoxicity
dc.subjectFerrocene
dc.subjectPlasmodium falciparum
dc.titleSynthesis, cytotoxicity and antimalarial activity of ferrocenyl amides of 4-aminoquinolinesen_US
dc.contributor.researchID20883072 - N'Da, David Dago
dc.contributor.researchID10059768 - Breytenbach, Jaco Cornelius


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record