Show simple item record

dc.contributor.authorOtto, A.en_US
dc.contributor.authorHadgraft, J.en_US
dc.contributor.authorDu Plessis, J.en_US
dc.contributor.authorWiechers, J.W.en_US
dc.contributor.authorKelly, C.L.en_US
dc.date.accessioned2012-02-29T09:49:51Z
dc.date.available2012-02-29T09:49:51Z
dc.date.issued2010en_US
dc.identifier.citationOtto, A. et al. 2010. Effect of emulsifiers and their liquid crystalline structures in emulsions on dermal and transdermal delivery of hydroquinone, salicylic acid and octadecenedioic acid. Skin pharmacology and physiology, 23(5):273-282. [https://doi.org/10.1159/000314702]en_US
dc.identifier.issn1660-5527en_US
dc.identifier.issn1660-5535en_US
dc.identifier.urihttp://hdl.handle.net/10394/6008
dc.identifier.urihttps://doi.org/10.1159/000314702
dc.identifier.urihttps://www.karger.com/Article/Abstract/314702
dc.description.abstractThis study investigated the effect of emulsifiers and their liquid crystalline structures on the dermal and transdermal delivery of hydroquinone (HQ), salicylic acid (SA) and octadecenedioic acid (DIOIC). Emulsions containing liquid crystalline phases were compared with an emulsion without liquid crystals. Skin permeation experiments were performed using Franz-type diffusion cells and human abdominal skin dermatomed to a thickness of 400 µm. The results indicate that emulsifiers arranging in liquid crystalline structures in the water phase of the emulsion enhanced the skin penetration of the active ingredients with the exception of SA. SA showed a different pattern of percutaneous absorption, and no difference in dermal and transdermal delivery was observed between the emulsions with and without liquid crystalline phases. The increase in skin penetration of HQ and DIOIC could be attributed to an increased partitioning of the actives into the skin. It was hypothesized that the interaction between the different emulsifiers and active ingredients in the formulations varied and, therefore, the solubilization capacities of the various emulsifiers and their association structures
dc.publisherKargeren_US
dc.titleEffect of emulsifiers and their liquid crystalline structures in emulsions on dermal and transdermal delivery of hydroquinone, salicylic acid and octadecenedioic aciden_US
dc.contributor.researchID12878332 - Otto, Anja
dc.contributor.researchID10065318 - Du Plessis, Jeanetta
dc.contributor.researchID12187372 - Hadgraft, Jonathan


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record