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dc.contributor.authorN'Da, David D.en_US
dc.contributor.authorBreytenbach, Jaco C.en_US
dc.contributor.authorBreytenbach, J. Wilhelminaen_US
dc.date.accessioned2012-02-29T09:51:49Z
dc.date.available2012-02-29T09:51:49Z
dc.date.issued2010en_US
dc.identifier.citationN'Da, D.D. et al. 2010. Synthesis and in vitro human skin penetration of oligo- and polymeric ethylene glycol carbonates of zidovudine and stavudine. Arzneimittel-Forschung / Drug research, 60(9):575-582. [http://dx.doi.org/10.1055/s-0031-1296328]en_US
dc.identifier.issn0004-4172en_US
dc.identifier.issn1616-7066 (Online)en_US
dc.identifier.urihttp://hdl.handle.net/10394/6038
dc.identifier.urihttp://dx.doi.org/10.1055/s-0031-1296328
dc.identifier.urihttps://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0031-1296328
dc.description.abstractIn continuation of studies focusing on the transdermal delivery of antiretroviral (ARV) drugs, the skin permeation ability of synthesized homologous series of both oligomeric and polymeric ethylene glycol (PEG) carbonates of zidovudine (3'-azido-3'-deoxythymidine, AZT, CAS 30516-87-1) and stavudine (2',3'-dideoxy-2',3'-didehydrothymine, d4T, CAS 3056-17-5) was evaluated in vitro through excised human skin in phosphate buffered solution (PBS) (0.01 M, pH 7.4) at 37°C by using Franz cell diffusion methodology. The results revealed that all the derivatives permeated the skin regardless of the series. However, the derivative having three ethylene glycol repeating units was the most effective permeant in each series. The skin permeation rates of zidovudine and stavudine were enhanced by factors in the 2-4, and 1-3 range through these carbonates, respectively
dc.publisherThiemeen_US
dc.subjectAntiretroviral drugs
dc.subjectEthylene glycol
dc.subjectEthylene oxide
dc.subjectPoly(ethylene glycol)
dc.subjectStavudine
dc.subjectTransdermal penetration
dc.subjectZidovudine
dc.titleSynthesis and in vitro human skin penetration of oligo- and polymeric ethylene glycol carbonates of zidovudine and stavudineen_US
dc.contributor.researchID10059768 - Breytenbach, Jaco Cornelius
dc.contributor.researchID20883072 - N'Da, David Dago
dc.contributor.researchID10187081 - Breytenbach, Johanna Wilhelmina


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