Major depression and models for new generations effective antidepressants / Christiaan Beyers Brink

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dc.contributor.author Brink, Christiaan Beyers
dc.date.accessioned 2012-03-15T12:01:11Z
dc.date.available 2012-03-15T12:01:11Z
dc.date.issued 2009
dc.identifier.isbn 9781868225828
dc.identifier.uri http://hdl.handle.net/10394/6311
dc.description.abstract (Afrikaans follows English / Afrikaans volg Engels) Major depression is a severe mood disorder, affecting the lives of more than a hundred million people world-wide, including in Africa. Yet existing effective treatment options, including antidepressant drugs, are insufficient, prompting and leaving many challenges for research. Major depression is a multi-factorial disorder, affecting multiple systems of the body. Even when focusing only on the central nervous system (brain -as it is primarily a psychiatric disorder by definition), there is a multitude of neurobiological functions that are affected in this disorder. Consequently there are several hypotheses to explain the neurobiological basis of depression and antidepressant action, and many approaches are needed to study this complex disorder and its treatment. This overview focuses on various pre-clinical approaches and techniques in neuropsychopharmacological research, particularly those implemented by the author in his research. It will review recent data on the effects of antidepressants on monoamine receptor Signalling, the implementation of ozone inhalation by rats as a model to investigate the role of oxidative stress in antidepressant action, and on a 'bench-to-behaviour' approach to investigate novel targets for antidepressant action (specifically the role of modulators of cGMP signalling). Secondly, the overview discusses current needs for capacity building in neuropsychopharmacology on the African continent, and strategies to address these needs. It reviews initiatives and projects with which the author have been involved to promote the sciences on the African continent, referring to international, continental and national role players. While there are several success stories and hope shared, the need to assist Africa to help and to identify and support leaders in science, is highlighted. It is concluded that success in science ultimately lies in compassion with your fellowman. Key words: Depression; antidepressants; neuroplasticity; oxidative stress; ozone; receptor signalling; cGMP; African initiative en_US
dc.publisher Potchefstroom : Noordwes-Universiteit, Potchefstroomkampus (Suid-Afrika) en_US
dc.relation.ispartofseries Wetenskaplike bydraes (North-West University (South Africa), Potchefstroom Campus). Reeks H, Inougurele rede ; nr. 232
dc.subject Antidepressants en_US
dc.subject Antidepressante en_US
dc.subject Depression - Mental en_US
dc.subject Depressie - Psigies en_US
dc.subject Neuroplasticity en_US
dc.subject Neuroplastisiteit en_US
dc.subject Neuropsychopharmacology en_US
dc.subject Neuropsigofarmakologie en_US
dc.subject Oxidative stress en_US
dc.subject Oksidatiewe stres en_US
dc.title Major depression and models for new generations effective antidepressants / Christiaan Beyers Brink en_US
dc.type Other en_US

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