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Tyrosinemia type I as a model for studying epigenetic events in the aetiology of metabolic disease associated hepatocarcinoma / Gouws, C.

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dc.contributor.author Gouws, Chrisna en_US
dc.date.accessioned 2012-08-23T13:19:56Z
dc.date.available 2012-08-23T13:19:56Z
dc.date.issued 2011 en_US
dc.identifier.uri http://hdl.handle.net/10394/7010
dc.description Thesis (Ph.D. (Biochemistry))--North-West University, Potchefstroom Campus, 2012.
dc.description.abstract Occupational risk management can be a catalyst in generating superior returns for all stakeholders on a sustainable basis. A number of companies in South Africa have implemented Cardinal Rules of Safety adopted from international companies to ensure the safety of their employees. The purpose of this study was to measure the impact of the cardinal rules on employee safety behaviour implemented at power stations in Mpumalanga. The empirical study was done by using a questionnaire as measuring instrument. The questionnaire was developed from a literature review and contains questions and items relevant to the initial research problem. The questionnaire comprised of five–point Likert scale type questions.The convenience sampling method was applied identifying 90 participants at three different power stations in Mpumalanga taking part in the study. Statistical analysis was performed by the Statistical Consulting Service of the North–West University using SPSS. Cronbach’s alpha co–efficients was used to determine the reliability of the factors. Descriptive statistics (Mean, standard, deviation, were used in the compiling of the profile of the results. While Spearman’s rho correlation coefficient was calculated to identify practically significant associations between variables and factors The research findings suggest that there is practical significant correlation between the factors that were measured. The opinion given by respondents suggests that cardinal rules of safety were implemented, given all the necessary support by management and enforced throughout the organisation. en_US
dc.publisher North-West University
dc.subject Hereditary tyrosinemia type 1 en_US
dc.subject Hepatocellular carcinoma en_US
dc.subject DNA methylation en_US
dc.subject DNA alkylation en_US
dc.subject Reactive oxygen species en_US
dc.subject Oxidative stress en_US
dc.subject Oorerflike tirosinemie tipe 1 en_US
dc.subject Hepatosellulêre karsinoom en_US
dc.subject DNS-metilering en_US
dc.subject DNS-alkilering en_US
dc.subject Reaktiewe suurstof spesies en_US
dc.subject Oksidatiewe stres en_US
dc.title Tyrosinemia type I as a model for studying epigenetic events in the aetiology of metabolic disease associated hepatocarcinoma / Gouws, C. en_US
dc.type Thesis en_US
dc.description.thesistype Doctoral en_US


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    This collection contains the original digitized versions of research conducted at the North-West University (Potchefstroom Campus)

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