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The antioxidant properties, cytotoxicity and monoamine oxidase inhibition abilities of the crude dichloromethane extract of Tarchonanthus camphoratus L. leaves

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dc.contributor.author Aiyegoro, Olayinka Ayobami
dc.contributor.author Van Dyk, Sandra
dc.date.accessioned 2012-08-28T13:21:21Z
dc.date.available 2012-08-28T13:21:21Z
dc.date.issued 2011
dc.identifier.citation Aiyegoro, O.A. & Van Dyk, S. 2011. The antioxidant properties, cytotoxicity and monoamine oxidase inhibition abilities of the crude dichloromethane extract of Tarchonanthus camphoratus L. leaves. African journal of biotechnology, 10(75):17297-17304. [http://www.academicjournals.org/AJB/index.htm] en_US
dc.identifier.issn 1684-5315
dc.identifier.uri http://hdl.handle.net/10394/7130
dc.description.abstract Tarchonanthus camphoratus (camphor bush) has been widely used for numerous medicinal purposes. The aim of the present study was to evaluate the antioxidant properties, cytotoxicity and monoamine oxidase inhibition activities of the crude dichloromethane leaf extract of T. camphoratus. The antioxidant activities were assessed using the thiobarbituric acid-reactive substances (TBARS) assay and the nitroblue tetrazolium (NBT) assay. The cytotoxicity assays were performed according to the microculture MTT method. From the MTT assay, it was determined that at a concentration of 10 mg/ml of crude extract, 95% of the neuroblastoma cells were killed. Almost 99% of the cells were viable at a concentration of 0.08 mg/ml extract. The extract also showed the ability to inhibit monoamine oxidase (MAO-A and MAO-B) with the corresponding inhibitory concentration, IC50 values of 1.371 and 0.2737 mg/ml, respectively. The antioxidant activity and cytotoxic effect of the extracts increased with increase in concentration. This study suggests that the dichloromethane leave extract of T. camphoratus can potentially be used as a readily accessible source of natural antioxidants. en_US
dc.description.uri http://www.academicjournals.org/AJB/PDF/pdf2011/28Nov/Aiyegoro%20and%20Van%20Dyk.pdf
dc.description.uri http://dx.doi.org/10.5897/AJB11.2249
dc.language.iso en en_US
dc.publisher Academic journals en_US
dc.subject Antioxidant en_US
dc.subject cytotoxicity en_US
dc.subject monoamine oxidase (MAO) en_US
dc.subject Tarchonanthus camphoratus en_US
dc.subject inhibitor en_US
dc.subject midicinal plant en_US
dc.title The antioxidant properties, cytotoxicity and monoamine oxidase inhibition abilities of the crude dichloromethane extract of Tarchonanthus camphoratus L. leaves en_US
dc.type Article en_US


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