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dc.contributor.authorAiyegoro, Olayinka Ayobami
dc.contributor.authorVan Dyk, Sandra
dc.date.accessioned2012-08-28T13:21:21Z
dc.date.available2012-08-28T13:21:21Z
dc.date.issued2011
dc.identifier.citationAiyegoro, O.A. & Van Dyk, S. 2011. The antioxidant properties, cytotoxicity and monoamine oxidase inhibition abilities of the crude dichloromethane extract of Tarchonanthus camphoratus L. leaves. African journal of biotechnology, 10(75):17297-17304. [http://www.academicjournals.org/AJB/index.htm]en_US
dc.identifier.issn1684-5315
dc.identifier.urihttp://hdl.handle.net/10394/7130
dc.description.abstractTarchonanthus camphoratus (camphor bush) has been widely used for numerous medicinal purposes. The aim of the present study was to evaluate the antioxidant properties, cytotoxicity and monoamine oxidase inhibition activities of the crude dichloromethane leaf extract of T. camphoratus. The antioxidant activities were assessed using the thiobarbituric acid-reactive substances (TBARS) assay and the nitroblue tetrazolium (NBT) assay. The cytotoxicity assays were performed according to the microculture MTT method. From the MTT assay, it was determined that at a concentration of 10 mg/ml of crude extract, 95% of the neuroblastoma cells were killed. Almost 99% of the cells were viable at a concentration of 0.08 mg/ml extract. The extract also showed the ability to inhibit monoamine oxidase (MAO-A and MAO-B) with the corresponding inhibitory concentration, IC50 values of 1.371 and 0.2737 mg/ml, respectively. The antioxidant activity and cytotoxic effect of the extracts increased with increase in concentration. This study suggests that the dichloromethane leave extract of T. camphoratus can potentially be used as a readily accessible source of natural antioxidants.en_US
dc.description.urihttp://www.academicjournals.org/AJB/PDF/pdf2011/28Nov/Aiyegoro%20and%20Van%20Dyk.pdf
dc.description.urihttp://dx.doi.org/10.5897/AJB11.2249
dc.language.isoenen_US
dc.publisherAcademic journalsen_US
dc.subjectAntioxidanten_US
dc.subjectcytotoxicityen_US
dc.subjectmonoamine oxidase (MAO)en_US
dc.subjectTarchonanthus camphoratusen_US
dc.subjectinhibitoren_US
dc.subjectmidicinal planten_US
dc.titleThe antioxidant properties, cytotoxicity and monoamine oxidase inhibition abilities of the crude dichloromethane extract of Tarchonanthus camphoratus L. leavesen_US
dc.typeArticleen_US


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