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dc.contributor.authorN'Da, David D.
dc.contributor.authorBreytenbach, Jaco C.
dc.contributor.authorSmith, Peter J.
dc.contributor.authorLategan, Carmen
dc.date.accessioned2012-09-03T09:32:38Z
dc.date.available2012-09-03T09:32:38Z
dc.date.issued2011
dc.identifier.citationN'Da, D.D. et al. 2011. Synthesis and in vitro antiplasmodial activity of quinoline-ferrocene esters. Arzneimittelforschung / Drug research, 61(6):358-365. [http://dx.doi.org/10.1055/s-0031-1296211]en_US
dc.identifier.issn0004-4172
dc.identifier.urihttp://hdl.handle.net/10394/7200
dc.identifier.urihttp://dx.doi.org/10.1055/s-0031-1296211
dc.identifier.urihttps://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0031-1296211
dc.description.abstractNew 4-aminoquinoline-derived esters containing the redox-active ferrocene group brought in by either ferrocenyformic or 4-ferrocenylbutanoic acids were synthesized and tested in vitro for their antiplasmodial activity. The results revealed that only esters derived from ferrocenylformic acid were active against both chloroquine (CQ)-resistant Dd2 and CQ-sensitive D10 strains of Plasmodium falciparum. However, none of these showed higher actvity than CQ against the sensitive strain. Ester 16, which possesses a butyl branch in the structure, was the most active of all. With an IC50 of 0.13 mM on the resistant strain, this ester possessed 2.5-fold higher activity than CQ (IC50 = 0.34 mM). All tested esters showed good selectivity towards P. falciparum with indexes higher than 60.en_US
dc.language.isoenen_US
dc.publisherThiemeen_US
dc.subjectAntiplasmodial activity
dc.subjectChloroquin
dc.subjectCytotoxicity
dc.subjectFerrocene
dc.subjectPlasmodium falciparum
dc.titleSynthesis and in vitro antiplasmodial activity of quinoline-ferrocene estersen_US
dc.typeArticleen_US
dc.contributor.researchID20883072 - N'Da, David Dago
dc.contributor.researchID10059768 - Breytenbach, Jaco Cornelius


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