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Metathesis access to monocyclic iminocyclitol-based therapeutic agents

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dc.contributor.author Delaude, Lionel
dc.contributor.author Demonceau, Albert
dc.contributor.author Dragutan, Ileana
dc.contributor.author Dragutan, Valerian
dc.contributor.author Mitan, Carmen
dc.contributor.author Vosloo, Hermanus Cornelius Moolman
dc.date.accessioned 2012-09-10T12:45:06Z
dc.date.available 2012-09-10T12:45:06Z
dc.date.issued 2011
dc.identifier.citation Dragutan, I. et al. 2011. Metathesis access to monocyclic iminocyclitol-based therapeutic agents. Beilstein journal of organic chemistry, 7:699-716. [http://www.beilstein-journals.org/bjoc/home/home.htm] en_US
dc.identifier.issn 1860-5397
dc.identifier.uri http://hdl.handle.net/10394/7262
dc.description.abstract By focusing on recent developments on natural and non-natural azasugars (iminocyclitols), this review bolsters the case for the role of olefin metathesis reactions (RCM, CM) as key transformations in the multistep syntheses of pyrrolidine-, piperidine- and azepane-based iminocyclitols, as important therapeutic agents against a range of common diseases and as tools for studying metabolic disorders. Considerable improvements brought about by introduction of one or more metathesis steps are outlined, with emphasis on the exquisite steric control and atom-economical outcome of the overall process. The comparative performance of several established metathesis catalysts is also highlighted. en_US
dc.description.uri http://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-7-81.pdf
dc.description.uri http://dx.doi.org/10.3762/bjoc.7.81
dc.language.iso en en_US
dc.publisher Beilstein Institut en_US
dc.subject Azasugars en_US
dc.subject iminocyclitols en_US
dc.subject natural products en_US
dc.subject olefin metathesis en_US
dc.subject Ru-alkylidene catalysts en_US
dc.title Metathesis access to monocyclic iminocyclitol-based therapeutic agents en_US
dc.type Article en_US


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