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dc.contributor.authorDelaude, Lionel
dc.contributor.authorDemonceau, Albert
dc.contributor.authorDragutan, Ileana
dc.contributor.authorDragutan, Valerian
dc.contributor.authorMitan, Carmen
dc.contributor.authorVosloo, Hermanus Cornelius Moolman
dc.date.accessioned2012-09-10T12:45:06Z
dc.date.available2012-09-10T12:45:06Z
dc.date.issued2011
dc.identifier.citationDragutan, I. et al. 2011. Metathesis access to monocyclic iminocyclitol-based therapeutic agents. Beilstein journal of organic chemistry, 7:699-716. [http://www.beilstein-journals.org/bjoc/home/home.htm]en_US
dc.identifier.issn1860-5397
dc.identifier.urihttp://hdl.handle.net/10394/7262
dc.description.abstractBy focusing on recent developments on natural and non-natural azasugars (iminocyclitols), this review bolsters the case for the role of olefin metathesis reactions (RCM, CM) as key transformations in the multistep syntheses of pyrrolidine-, piperidine- and azepane-based iminocyclitols, as important therapeutic agents against a range of common diseases and as tools for studying metabolic disorders. Considerable improvements brought about by introduction of one or more metathesis steps are outlined, with emphasis on the exquisite steric control and atom-economical outcome of the overall process. The comparative performance of several established metathesis catalysts is also highlighted.en_US
dc.description.urihttp://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-7-81.pdf
dc.description.urihttp://dx.doi.org/10.3762/bjoc.7.81
dc.language.isoenen_US
dc.publisherBeilstein Instituten_US
dc.subjectAzasugarsen_US
dc.subjectiminocyclitolsen_US
dc.subjectnatural productsen_US
dc.subjectolefin metathesisen_US
dc.subjectRu-alkylidene catalystsen_US
dc.titleMetathesis access to monocyclic iminocyclitol-based therapeutic agentsen_US
dc.typeArticleen_US


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