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Dissociation between learning and memory impairment and other sickness behaviours during simulated Mycoplasma infection in rats

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dc.contributor.author Harvey, Brian Herbert
dc.contributor.author Mitchell, Duncan
dc.contributor.author Swanepoel, Tanya
dc.contributor.author Harden, Lois M.
dc.contributor.author Laburn, Helen P.
dc.date.accessioned 2012-09-17T10:13:35Z
dc.date.available 2012-09-17T10:13:35Z
dc.date.issued 2011
dc.identifier.citation Swanepoel, T. et al. 2011. Dissociation between learning and memory impairment and other sickness behaviours during simulated Mycoplasma infection in rats. Brain behavior and immunity, 25(8):1607-1616. [http://www.journals.elsevier.com/brain-behavior-and-immunity/] en_US
dc.identifier.issn 0889-1591 (Online)
dc.identifier.issn 0889-1591
dc.identifier.uri http://hdl.handle.net/10394/7391
dc.description.abstract To investigate potential consequences for learning and memory, we have simulated the effects of Mycoplasma infection, in rats, by administering fibroblast-stimulating lipopepide-1 (FSL-1), a pyrogenic moiety of Mycoplasma salivarium. We measured the effects on body temperature, cage activity, food intake, and on spatial learning and memory in a Morris Water Maze. Male Sprague-Dawley rats had radio transponders implanted to measure abdominal temperature and cage activity. After recovery, rats were assigned randomly to receive intraperitoneal (I.P.) injections of FSL-1 (500 or 1000 µg kg-1 in 1 ml kg-1 phosphate- buffered saline; PBS) or vehicle(PBS, 1 ml kg_1). Body mass and food intake were measured daily. Training in the Maze commenced 18 h after injections and continued daily for four days. Spatial memory was assessed on the fifth day. In other rats, we measured concentrations of brain pro-inflammatory cytokines, interleukin (IL)-1b and IL-6, at 3 and 18 h after injections. FSL-1 administration induced a dosedependent fever (_1 _C) for two days, lethargy (_78%) for four days, anorexia (_65%) for three days and body mass stunting (_6%) for at least four days. Eighteen hours after FSL-1 administration, when concentrations of IL-1b, but not that of IL-6, were elevated in both the hypothalamus and the hippocampus, and when rats were febrile, lethargic and anorexic, learning in the Maze was unaffected. There also was no memory impairment. Our results support emerging evidence that impaired learning and memory is not inevitable during simulated infection. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Rat en_US
dc.subject systemic infection en_US
dc.subject learning and memory en_US
dc.subject Morris water maze en_US
dc.subject Interleukin (IL)-1b en_US
dc.subject IL-6 en_US
dc.subject hippocampus en_US
dc.subject hypothalamus en_US
dc.title Dissociation between learning and memory impairment and other sickness behaviours during simulated Mycoplasma infection in rats en_US
dc.type Article en_US


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