Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?

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dc.contributor.author Conradie, Karin Ronel
dc.contributor.author Fourie, Catharina Maria Theresia
dc.contributor.author Hoekstra, Tiny
dc.contributor.author Pieters, Marlien
dc.contributor.author Schutte, Aletta Elisabeth
dc.contributor.author Van Rooyen, Johannes Marthinus
dc.date.accessioned 2012-09-18T08:46:47Z
dc.date.available 2012-09-18T08:46:47Z
dc.date.issued 2011
dc.identifier.citation Fourie, C.M.T. et al. 2011. Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?. Cardiovascular journal of Africa, 22(3):134-140. [http://www.cvja.co.za/information.php] en_US
dc.identifier.issn 1995-1892
dc.identifier.issn 1996-3467 (Online)
dc.identifier.uri http://hdl.handle.net/10394/7393
dc.description CVJA is the official journal of the PASCAR (Pan African Society of Cardiology) en_US
dc.description.abstract The chronic infection status suffered by HIV-infected individuals promotes chronic arterial inflammation and injury, which leads to dysfunction of the endothelium, atherosclerosis and thrombosis. Although HIV-1 subtype C is prevalent in South Africa and accounts for almost a third of the infections worldwide, this subtype differs genetically from HIV-1 subtype B on which the majority of studies have been done. The objective of this study was to assess whether newly identified, never-treated, HIV-1-infected South African participants showed signs of endothelial dysfunction, accelerated atherosclerosis and increased blood coagulation. We compared 300 newly diagnosed (never antiretroviral-treated) HIV-infected participants to 300 age-, gender-, body mass index- and locality-matched uninfected controls. Levels of high-density lipoprotein cholesterol (HDL-C), triglycerides, interleukin-6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), fibrinogen and plasminogen activator inhibitor-1 (PAI-1), and carotid radialis pulse wave velocity (cr-PWV) were determined. The HIV-infected participants showed lower HDL-C and higher IL-6, CRP, ICAM-1 and VCAM-1 levels compared to the uninfected controls. No differences in fibrinogen and PAI-1 levels were detected. A continuous positive trend of increasing age with cr-PWV was detected in the HIV-infected group. Our findings suggest inflammatory injury of the endothelium, pointing to endothelial dysfunction of never-treated HIV-1-infected South Africans of African ancestry. Although no indication of a prothrombotic state could be detected, there was an indication of accelerated vascular aging and probable early atherosclerosis in the older HIV-infected participants. en_US
dc.description.uri http://dx.doi.org/10.5830/CVJA-2010-056
dc.language.iso en en_US
dc.publisher Clinics Cardive en_US
dc.subject HIV-1 en_US
dc.subject endothelial dysfuncion en_US
dc.subject vascular aging en_US
dc.subject never treated en_US
dc.subject inflammation en_US
dc.title Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa? en_US
dc.type Article en_US

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