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dc.contributor.authorHuisman, Hugo Willem
dc.contributor.authorMalan, Nicolaas Theodor
dc.contributor.authorSchutte, Aletta Elisabeth
dc.contributor.authorSchutte, Rudolph
dc.contributor.authorVan Rooyen, Johannes Marthinus
dc.contributor.authorMalan, Leoné
dc.contributor.authorReimann, Manja
dc.date.accessioned2012-09-19T09:46:44Z
dc.date.available2012-09-19T09:46:44Z
dc.date.issued2011
dc.identifier.citationSchutte, A.E. et al. 2011. Arterial stiffness profiles: investigating various sections of the arterial tree of African and caucasian people. Clinical and experimental hypertension, 33(8):511-517. [http://dx.doi.org/10.3109/10641963.2011.561897]en_US
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/7402
dc.identifier.urihttp://dx.doi.org/10.3109/10641963.2011.561897
dc.description.abstractIn Africans, arterial stiffness progression seems more pronounced compared to Caucasians. We compared the arterial stiffness profiles of different age groups and focused on muscular arteries and two more central arterial segments in African and Caucasian people from South Africa. In African (N = 374) and Caucasian (N = 376) participants (20–70 years), we measured carotid-radial (C-R) and carotid-dorsalis pedis (C-DP) pulse wave velocity (PWV) and aortic characteristic impedance (Zao). Major findings were that normotensive and high-normal/hypertensive (HT) Caucasians indicated increased trends of C-R PWV with aging (P = .029 and P = .067), not seen in the African groups (P = .122 and P = .526). Both ethnic groups showed significant increases of C-DP PWV and Zao with aging. High-normal/hypertensive Africans had significantly stiffer arteries than hypertensive Caucasians for almost all age groups, and for all stiffness measures. African C-R PWV correlated significantly with blood pressure (BP), but not with age. Opposite results were observed for Caucasians. In conclusion, the stiffness of muscular arteries is already elevated in young Africans, in both those with normal or elevated BP. This is possibly due to an earlier deterioration during childhood, or perhaps already present from birth. Also, in Caucasians stiffness seems more age-related, while in Africans it seems to be more pressure-related.en_US
dc.language.isoenen_US
dc.publisherInforma healthcareen_US
dc.subjectArterial stiffnessen_US
dc.subjectethnicityen_US
dc.subjectAfricansen_US
dc.subjectagingen_US
dc.subjectmuscular arteriesen_US
dc.titleArterial stiffness profiles: investigating various sections of the arterial tree of African and caucasian peopleen_US
dc.typeArticleen_US
dc.contributor.researchID10062718 - Huisman, Hugo Willem
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID12201405 - Schutte, Rudolph
dc.contributor.researchID10059539 - Van Rooyen, Johannes Marthinus


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