Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration
Date
2011Author
Möller, Marisa
Du Preez, Jan L.
Harvey, Brian H.
Emsley, Robin
Metadata
Show full item recordAbstract
Social isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to schizophrenia. We studied the effects of 8 weeks SIR on cortico-striatal redox and social and cognitive behaviors in rats. SIR increased superoxide dismutase activity, decreased oxidized:reduced glutathione ratio and increased lipid peroxidation in both brain regions, and induced deficits in prepulse inhibition and social and self-directed interactive behaviors. Both behavioral and cortico-striatal redox disturbances were corrected by clozapine (5 mg/kg/day × 11 days). Behavioral changes evoked by SIR are associated with cortico-striatal oxidative stress that is reversed by clozapine treatment, providing novel insight into the neurobiology and treatment of schizophrenia.
URI
http://hdl.handle.net/10394/7441https://www.sciencedirect.com/science/article/pii/S0924977X1000194X
https://doi.org/10.1016/j.euroneuro.2010.09.006
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- Faculty of Health Sciences [2377]