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Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico–striatal oxidative stress, and reversed by sub-chronic clozapine administration

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dc.contributor.author Emsley, Robin
dc.contributor.author Harvey, Brian Herbert
dc.contributor.author Möller, Marisa
dc.contributor.author Du Preez, Jan Lourens
dc.date.accessioned 2012-10-05T07:23:02Z
dc.date.available 2012-10-05T07:23:02Z
dc.date.issued 2011
dc.identifier.citation Möller, M. et al. 2011.Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico–striatal oxidative stress, and reversed by sub-chronic clozapine administration. European neuropsychopharmacology, 21(6):471-483. [http://www.journals.elsevier.com/european-neuropsychopharmacology/#description] [http://www.europeanneuropsychopharmacology.com/] en_US
dc.identifier.issn 0924-977X
dc.identifier.issn 1873-7862 (Online)
dc.identifier.uri http://hdl.handle.net/10394/7441
dc.description The journal of the European College of Neuropsychopharmacology en_US
dc.description.abstract Social isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to schizophrenia. We studied the effects of 8 weeks SIR on cortico-striatal redox and social and cognitive behaviors in rats. SIR increased superoxide dismutase activity, decreased oxidized:reduced glutathione ratio and increased lipid peroxidation in both brain regions, and induced deficits in prepulse inhibition and social and self-directed interactive behaviors. Both behavioral and cortico-striatal redox disturbances were corrected by clozapine (5 mg/kg/day × 11 days). Behavioral changes evoked by SIR are associated with cortico-striatal oxidative stress that is reversed by clozapine treatment, providing novel insight into the neurobiology and treatment of schizophrenia. en_US
dc.description.uri http://dx.doi.org/10.1016/j.euroneuro.2010.09.006
dc.language.iso en en_US
dc.publisher Elsevier Science en_US
dc.subject Social isolation en_US
dc.subject prepulse inhibition en_US
dc.subject social interaction en_US
dc.subject clozapine en_US
dc.subject schizophrenia en_US
dc.subject animal model en_US
dc.subject oxidative stress en_US
dc.title Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico–striatal oxidative stress, and reversed by sub-chronic clozapine administration en_US
dc.type Article en_US


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