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Arterial stiffness, ambulatory blood pressure and low-grade albuminuria in non-diabetic African and caucasian men: the SABPA study

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dc.contributor.author Fourie, Catharina Maria Theresia
dc.contributor.author Glyn, Matthew Colin Patrick
dc.contributor.author Huisman, Hugo Willem
dc.contributor.author Malan, Nicolaas Theodor
dc.contributor.author Schutte, Aletta Elisabeth
dc.contributor.author Schutte, Rudolph
dc.contributor.author Van Rooyen, Johannes Marthinus
dc.contributor.author Malan, Leoné
dc.date.accessioned 2012-10-11T10:34:01Z
dc.date.available 2012-10-11T10:34:01Z
dc.date.issued 2011
dc.identifier.citation Schutte, R. et al. 2011. Arterial stiffness, ambulatory blood pressure and low-grade albuminuria in non-diabetic African and caucasian men: the SABPA study. Hypertension research, 34(7):862-868. [http://www.nature.com/hr/index.html] en_US
dc.identifier.issn 0916-9636
dc.identifier.issn 1348-4214 (Online)
dc.identifier.uri http://hdl.handle.net/10394/7473
dc.description Official journal of the Japanese Society of Hypertension en_US
dc.description.abstract Recent evidence suggests that low-grade urinary albumin excretion is a marker of early general attenuation of vascular function, but studies are limited to Caucasian population groups. We compared low-grade urinary albumin excretion (<3.5 mg mmol−1 or 30 μg mg−1) between non-diabetic African (aged, 41.7 years; n=70) and Caucasian (aged, 44.6 years; n=91) men and ethnic-specific associations thereof with arterial stiffness and ambulatory blood pressure. The albumin-to-creatinine ratio (ACR) was determined from an 8 h overnight urine collection. We recorded ambulatory blood pressure over 24 h during a typical workday and the carotid–dorsalis pedis pulse wave velocity measured the next morning after a controlled overnight stay. ACR was higher in Africans compared with Caucasians (P<0.001), also after adjusting for 24 h systolic blood pressure, diastolic blood pressure and hypertension prevalence (P<0.001) or when grouped by similar 24 h mean arterial pressures (P<0.01 for all categories). Daytime (P=0.002) and night time (P< 0.001) systolic and daytime (P<0.001) and night time (P<0.001) diastolic blood pressures were higher in Africans compared with Caucasians, but no differences existed for daytime and night time pulse pressure and pulse wave velocity. In African men only, after adjustment for covariates, night time systolic blood pressure (β=0.347; P=0.003), diastolic blood pressure (β=0.298; P=0.010) and mean arterial pressure (β=0.331; P=0.004) correlated positively with ACR. In addition, daytime (β=0.265; P=0.032) and night time (β=0.258; P=0.038) pulse pressure as well as pulse wave velocity (β=0.271; P=0.032) correlated positively with ACR. In conclusion, arterial stiffness and ambulatory blood pressure are already associated with low-grade albuminuria in non-diabetic African men with normal kidney function. en_US
dc.description.uri http://dx.doi.org/10.1038/hr.2011.45
dc.language.iso en en_US
dc.publisher Nature Publishing Group en_US
dc.subject Albuminuria en_US
dc.subject ambulatory blood pressure en_US
dc.subject arterial stiffness en_US
dc.subject ethnicity en_US
dc.title Arterial stiffness, ambulatory blood pressure and low-grade albuminuria in non-diabetic African and caucasian men: the SABPA study en_US
dc.type Article en_US


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