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dc.contributor.authorFourie, Catharina Maria Theresia
dc.contributor.authorHuisman, Hugo Willem
dc.contributor.authorMalan, Nicolaas Theodor
dc.contributor.authorSchutte, Aletta Elisabeth
dc.contributor.authorSchutte, Rudolph
dc.contributor.authorVan Rooyen, Johannes Marthinus
dc.contributor.authorMalan, Leoné
dc.date.accessioned2012-10-11T10:53:55Z
dc.date.available2012-10-11T10:53:55Z
dc.date.issued2011
dc.identifier.citationSchutte, A.E. et al. 2011. Blood pressure variability is significantly associated with ECG left ventricular mass in normotensive Africans: the SABPA study. Hypertension research, 34(10):1127-1134. [http://www.nature.com/hr/index.html]en_US
dc.identifier.issn0916-9636
dc.identifier.issn1348-4214 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/7474
dc.descriptionOfficial journal of the Japanese Society of Hypertensionen_US
dc.description.abstractThe prognostic significance of blood pressure (BP) variability has lately enjoyed considerable attention. The need for early markers of cardiovascular dysfunction is imperative in black South Africans who have a significant risk for cardiovascular disease. We therefore compared 24-h BP variability with various traditional and advanced BP measurements, regarding their association with sub-clinical organ damage in black and white South Africans. The study included 409 African and Caucasian teachers aged 25–60 yrs. We measured office BP, 1-min continuous (finger) BP, ambulatory BP, BP reactivity and determined weighted 24-h BP variability. Albumin-to-creatinine ratio, Cornell product and carotid cross-sectional wall area (CSWA) were measures of organ damage. Africans had higher 24-h BP, BP variability, BP reactivity and sub-clinical organ damage (P<0.001). Correlations of BP variability with organ damage were overall weak when compared with other BP measurements. In normotensive groups, we found an independent association of 24-h systolic BP (SBP) variability with Cornell product only in Africans (r=0.37; P=0.01), confirmed in multiple regression models, with 24-h SBP included in the model. Only in hypertensive Caucasians, a significant correlation between CSWA and 24-h SBP variability was evident (r=0.30; P=0.01), although CSWA indicated stronger correlations with office or 24-h SBP than 24-h SBP variability. To conclude, 24-h SBP variability could potentially be an effective measure for the early detection of normotensive Africans at increased risk for the development of cardiovascular complications. Its usefulness based on associations with target organ damage in hypertensive groups seems to be less than traditional office or 24-h BP measurements.en_US
dc.description.urihttp://dx.doi.org/10.1038/hr.2011.104
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.subjectAlbumin-to-creatinine ratioen_US
dc.subjectethnicityen_US
dc.subjectintima-media thicknessen_US
dc.subjectleft ventricular hypertrophyen_US
dc.titleBlood pressure variability is significantly associated with ECG left ventricular mass in normotensive Africans: the SABPA studyen_US
dc.typeArticleen_US


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