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Blood pressure variability is significantly associated with ECG left ventricular mass in normotensive Africans: the SABPA study

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dc.contributor.author Fourie, Catharina Maria Theresia
dc.contributor.author Huisman, Hugo Willem
dc.contributor.author Malan, Nicolaas Theodor
dc.contributor.author Schutte, Aletta Elisabeth
dc.contributor.author Schutte, Rudolph
dc.contributor.author Van Rooyen, Johannes Marthinus
dc.contributor.author Malan, Leoné
dc.date.accessioned 2012-10-11T10:53:55Z
dc.date.available 2012-10-11T10:53:55Z
dc.date.issued 2011
dc.identifier.citation Schutte, A.E. et al. 2011. Blood pressure variability is significantly associated with ECG left ventricular mass in normotensive Africans: the SABPA study. Hypertension research, 34(10):1127-1134. [http://www.nature.com/hr/index.html] en_US
dc.identifier.issn 0916-9636
dc.identifier.issn 1348-4214 (Online)
dc.identifier.uri http://hdl.handle.net/10394/7474
dc.description Official journal of the Japanese Society of Hypertension en_US
dc.description.abstract The prognostic significance of blood pressure (BP) variability has lately enjoyed considerable attention. The need for early markers of cardiovascular dysfunction is imperative in black South Africans who have a significant risk for cardiovascular disease. We therefore compared 24-h BP variability with various traditional and advanced BP measurements, regarding their association with sub-clinical organ damage in black and white South Africans. The study included 409 African and Caucasian teachers aged 25–60 yrs. We measured office BP, 1-min continuous (finger) BP, ambulatory BP, BP reactivity and determined weighted 24-h BP variability. Albumin-to-creatinine ratio, Cornell product and carotid cross-sectional wall area (CSWA) were measures of organ damage. Africans had higher 24-h BP, BP variability, BP reactivity and sub-clinical organ damage (P<0.001). Correlations of BP variability with organ damage were overall weak when compared with other BP measurements. In normotensive groups, we found an independent association of 24-h systolic BP (SBP) variability with Cornell product only in Africans (r=0.37; P=0.01), confirmed in multiple regression models, with 24-h SBP included in the model. Only in hypertensive Caucasians, a significant correlation between CSWA and 24-h SBP variability was evident (r=0.30; P=0.01), although CSWA indicated stronger correlations with office or 24-h SBP than 24-h SBP variability. To conclude, 24-h SBP variability could potentially be an effective measure for the early detection of normotensive Africans at increased risk for the development of cardiovascular complications. Its usefulness based on associations with target organ damage in hypertensive groups seems to be less than traditional office or 24-h BP measurements. en_US
dc.description.uri http://dx.doi.org/10.1038/hr.2011.104
dc.language.iso en en_US
dc.publisher Nature Publishing Group en_US
dc.subject Albumin-to-creatinine ratio en_US
dc.subject ethnicity en_US
dc.subject intima-media thickness en_US
dc.subject left ventricular hypertrophy en_US
dc.title Blood pressure variability is significantly associated with ECG left ventricular mass in normotensive Africans: the SABPA study en_US
dc.type Article en_US


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