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Preparation and characterization of directly compactible layer-by-layer nanocoated cellulose

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dc.contributor.author Liebenberg, Wilna
dc.contributor.author Strydom, Schalk J.
dc.contributor.author Otto, Daniel P.
dc.contributor.author Lvov, Yuri M.
dc.contributor.author De Villiers, Melgardt M,
dc.date.accessioned 2012-10-19T13:42:05Z
dc.date.available 2012-10-19T13:42:05Z
dc.date.issued 2011
dc.identifier.citation Strydom, S.J. et al. 2011. Preparation and characterization of directly compactible layer-by-layer nanocoated cellulose. International journal of pharmaceutics, 40(1-2)4:57-65. [http://dx.doi.org/10.1016/j.ijpharm.2010.10.056] en_US
dc.identifier.issn 0378-5173
dc.identifier.issn 1873-3476 (Online)
dc.identifier.uri http://hdl.handle.net/10394/7532
dc.description.abstract Microcrystalline cellulose is a commonly used direct compression tablet diluent and binder. It is derived from purified α-cellulose in an environmentally unfriendly process that involves mineral acid catalysed hydrolysis. In this study Kraft softwood fibers was nanocoated using a layer-by-layer self-assembling process. Powder flow and compactibility results showed that the application of nano-thin polymer layers on the fibers turned non-flowing, non-compacting cellulose into powders that can be used in the direct compression of tablets. The powder flow properties and tableting indices of compacts compressed from these nanocoated microfibers were similar or better than that of directly compactible microcrystalline cellulose powders. Cellulose microfibers coated with four PSS/PVP bilayers had the best compaction properties while still producing tablets that were able to absorb water and disintegrate and did not retard the dissolution of a model drug acetaminophen. The advantages of nanocoating rather than traditional pharmaceutical coating are that it add less than 1% to the weight of the fibers and allows control of the molecular properties of the surface and the thickness of the coat to within a few nanometers. This process is potentially friendlier to the environment because of the type and quantity of materials used. Also, it does not involve acid-catalyzed hydrolysis and neutralization of depolymerized cellulose. en_US
dc.description.uri http://dx.doi.org/10.1016/j.ijpharm.2010.10.056
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Layer-by-layer en_US
dc.subject self-assembling en_US
dc.subject nanocoating en_US
dc.subject cellulose en_US
dc.subject direct compression en_US
dc.title Preparation and characterization of directly compactible layer-by-layer nanocoated cellulose en_US
dc.type Article en_US


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