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A micronutrient powder with low doses of highly absorbable iron and zinc reduces iron and zinc deficiency and improves weight-for-age z-scores in South African children

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dc.contributor.author Smuts, Cornelius Mattheus
dc.contributor.author Troesch, Barbara
dc.contributor.author Van Stujivenberg, Martha E.
dc.contributor.author Kruger, Herculina Salomè
dc.contributor.author Biebinger, Ralf
dc.date.accessioned 2012-10-29T04:48:42Z
dc.date.available 2012-10-29T04:48:42Z
dc.date.issued 2011
dc.identifier.citation Troesch, B. et al. 2011. A micronutrient powder with low doses of highly absorbable iron and zinc reduces iron and zinc deficiency and improves weight-for-age z-scores in South African children. Journal of nutrition, 141(2):237-242. [http://www.nutrition.org/publications/the-journal-of-nutrition/] en_US
dc.identifier.issn 0022-3166
dc.identifier.issn 1541-6100 (Online)
dc.identifier.uri http://hdl.handle.net/10394/7654
dc.description.abstract Micronutrient powders (MNP) are often added to complementary foods high in inhibitors of iron and zinc absorption. Most MNP therefore include high amounts of iron and zinc, but it is no longer recommended in malarial areas to use untargeted MNP that contain the Reference Nutrient Intake for iron in a single serving. The aim was to test the efficacy of a low-iron and -zinc (each 2.5 mg) MNP containing iron as NaFeEDTA, ascorbic acid (AA), and an exogenous phytase active at gut pH. In a double-blind controlled trial, South African school children with low iron status (n = 200) were randomized to receive either the MNP or the unfortified carrier added just before consumption to a high-phytate maize porridge 5 d/wk for 23 wk; primary outcomes were iron and zinc status and a secondary outcome was somatic growth. Compared with the control, the MNP increased serum ferritin (P < 0.05), body iron stores (P < 0.01) and weight-for-age Z-scores (P < 0.05) and decreased transferrin receptor (P < 0.05). The prevalence of iron deficiency fell by 30.6% (P < 0.01) and the prevalence of zinc deficiency decreased by 11.8% (P < 0.05). Absorption of iron from the MNP was estimated to be 7–8%. Inclusion of an exogenous phytase combined with NaFeEDTA and AA may allow a substantial reduction in the iron dose from existing MNP while still delivering adequate iron and zinc. In addition, the MNP is likely to enhance absorption of the high native iron content of complementary foods based on cereals and/or legumes. en_US
dc.description.uri http://dx.doi.org/10.3945/jn.110.129247
dc.language.iso en en_US
dc.publisher American Society of Nutrition en_US
dc.title A micronutrient powder with low doses of highly absorbable iron and zinc reduces iron and zinc deficiency and improves weight-for-age z-scores in South African children en_US
dc.type Article en_US


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