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dc.contributor.authorBergh, Jacobus Johannes
dc.contributor.authorMienie, Lodewyk Jacobus
dc.contributor.authorTerre'blanche, Gisella
dc.contributor.authorVan der Walt, Mietha Magdalena
dc.date.accessioned2012-11-06T04:38:30Z
dc.date.available2012-11-06T04:38:30Z
dc.date.issued2011
dc.identifier.citationTerre'blanche, G. et al. 2011. Treatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid-A case report. Lipids in health and disease, 10(152):1-6. [http://www.lipidworld.com/]en_US
dc.identifier.issn1476-511X
dc.identifier.urihttp://hdl.handle.net/10394/7719
dc.description.abstractThis is a case report of adrenomyeloneuropathy (AMN), the adult variant of adrenoleukodystryphy (ALD). The diagnoses in the patient, aged 34, was confirmed via increased serum very long chain fatty acid concentration (VLCFA). Treatment started with the cholesterol lowering drug, atorvastatin, followed by add-on therapy with Lorenzo's oil (LO) and finally supplementation with docosahexaenoic acid (DHA). The magnetic resonance imaging (MRI) scan of the AMN patient before DHA treatment, already showed abnormal white matter in the brain. Although the MRI showed no neurological improvement after 6 months of DHA treatment, no selective progression of demyelination was detected in the AMN patient. Contrary to what was expected, LO failed to sustain or normalize the VLCFA levels or improve clinical symptoms. It was however, shown that DHA supplementation in addition to LO, increased DHA levels in both plasma and red blood cells (RBC). Additionally, the study showed evidence that the elongase activity in the elongation of eicosapentaenoic acid (EPA) to docosapentaenoic acid (DPA) might have been significantly compromised, due to the increased DHA levels.en_US
dc.description.urihttp://dx.doi.org/10.1186/1476-511X-10-152
dc.description.urihttp://www.lipidworld.com/content/pdf/1476-511X-10-152.pdf
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.subjectAdrenoleukodystrophyen_US
dc.subjectadrenomyeloneuropathyen_US
dc.subjectLorenzo's oilen_US
dc.subjectdocosahexaenoic aciden_US
dc.subjectpolyunsaturated fatty acidsen_US
dc.titleTreatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid-A case reporten_US
dc.typeArticleen_US


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