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Treatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid-A case report

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dc.contributor.author Bergh, Jacobus Johannes
dc.contributor.author Mienie, Lodewyk Jacobus
dc.contributor.author Terre'blanche, Gisella
dc.contributor.author Van der Walt, Mietha Magdalena
dc.date.accessioned 2012-11-06T04:38:30Z
dc.date.available 2012-11-06T04:38:30Z
dc.date.issued 2011
dc.identifier.citation Terre'blanche, G. et al. 2011. Treatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid-A case report. Lipids in health and disease, 10(152):1-6. [http://www.lipidworld.com/] en_US
dc.identifier.issn 1476-511X
dc.identifier.uri http://hdl.handle.net/10394/7719
dc.description.abstract This is a case report of adrenomyeloneuropathy (AMN), the adult variant of adrenoleukodystryphy (ALD). The diagnoses in the patient, aged 34, was confirmed via increased serum very long chain fatty acid concentration (VLCFA). Treatment started with the cholesterol lowering drug, atorvastatin, followed by add-on therapy with Lorenzo's oil (LO) and finally supplementation with docosahexaenoic acid (DHA). The magnetic resonance imaging (MRI) scan of the AMN patient before DHA treatment, already showed abnormal white matter in the brain. Although the MRI showed no neurological improvement after 6 months of DHA treatment, no selective progression of demyelination was detected in the AMN patient. Contrary to what was expected, LO failed to sustain or normalize the VLCFA levels or improve clinical symptoms. It was however, shown that DHA supplementation in addition to LO, increased DHA levels in both plasma and red blood cells (RBC). Additionally, the study showed evidence that the elongase activity in the elongation of eicosapentaenoic acid (EPA) to docosapentaenoic acid (DPA) might have been significantly compromised, due to the increased DHA levels. en_US
dc.description.uri http://dx.doi.org/10.1186/1476-511X-10-152
dc.description.uri http://www.lipidworld.com/content/pdf/1476-511X-10-152.pdf
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.subject Adrenoleukodystrophy en_US
dc.subject adrenomyeloneuropathy en_US
dc.subject Lorenzo's oil en_US
dc.subject docosahexaenoic acid en_US
dc.subject polyunsaturated fatty acids en_US
dc.title Treatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid-A case report en_US
dc.type Article en_US


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