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O6-methylguanine-DNA methyltransferase (MGMT): can function explain a suicidal mechanism?

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dc.contributor.author Gouws, Chrisna
dc.contributor.author Pretorius, Petrus Jacobus
dc.date.accessioned 2012-11-08T08:30:12Z
dc.date.available 2012-11-08T08:30:12Z
dc.date.issued 2011
dc.identifier.citation Gouws, C. & Pretorius, P.J. 2011. O6-methylguanine-DNA methyltransferase (MGMT): can function explain a suicidal mechanism? Medical hypotheses, 77(5):857-860. [http://www.journals.elsevier.com/medical-hypotheses/] en_US
dc.identifier.issn 0306-9877
dc.identifier.issn 1532-2777 (Online)
dc.identifier.uri http://hdl.handle.net/10394/7739
dc.description.abstract Why does O6-methylguanine-DNA methyltransferase (MGMT), an indispensable DNA repair enzyme, have a mechanism which seems to run counter to its importance? This enzyme is key to the removal of detrimental alkyl adducts from guanine bases. Although the mechanism is well known, an unusual feature surrounds its mode of action, which is its so-called suicidal endpoint. In addition, induction of MGMT is highly variable and its kinetics is atypical. These features raise some questions on the seemingly paradoxical mechanism. In this manuscript we point out that, although there is ample literature regarding the “how” of the MGMT enzyme, we found a lack of information on “why” this specific mechanism is in place. We then ask whether we know all there is to know about MGMT, or if perhaps there is a further as yet unknown function for MGMT, or if the suicidal mechanism may play some kind of protective role in the cell. en_US
dc.description.uri DOI: http://dx.doi.org/10.1016/j.mehy.2011.07.055
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.title O6-methylguanine-DNA methyltransferase (MGMT): can function explain a suicidal mechanism? en_US
dc.type Article en_US


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