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dc.contributor.authorBourne, Susan
dc.contributor.authorCaira, Mino
dc.contributor.authorLi, Jinjing
dc.contributor.authorLiebenberg, Wilna
dc.contributor.authorStrydom, Schalk Johannes
dc.contributor.authorDe Villiers, Melgardt M.
dc.date.accessioned2012-11-09T09:34:20Z
dc.date.available2012-11-09T09:34:20Z
dc.date.issued2011
dc.identifier.citationDe Villiers, M. et al. 2011. Crystallization of toxic glycol solvates of rifampin from glycerin and propylene glycol contaminated with ethylene glycol or diethylene glycol. Molecular pharmaceutics, 8(3):877-888. [http://pubs.acs.org/journal/mpohbp/about.htm]en_US
dc.identifier.issn1543-8384
dc.identifier.issn1543-8392 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/7745
dc.description.abstractThis study was initiated when it was suspected that syringe blockage experienced upon administration of a compounded rifampin suspension was caused by the recrystallization of toxic glycol solvates of the drug. Single crystal X-ray structure analysis, powder X-ray diffraction, thermal analysis and gas chromatography were used to identify the ethylene glycol in the solvate crystals recovered from the suspension. Controlled crystallization and solubility studies were used to determine the ease with which toxic glycol solvates crystallized from glycerin and propylene glycol contaminated with either ethylene or diethylene glycol. The single crystal structures of two distinct ethylene glycol solvates of rifampin were solved while thermal analysis, GC analysis and solubility studies confirmed that diethylene glycol solvates of the drug also crystallized. Controlled crystallization studies showed that crystallization of the rifampin solvates from glycerin and propylene glycol depended on the level of contamination and changes in the solubility of the drug in the contaminated solvents. Although the exact source of the ethylene glycol found in the compounded rifampin suspension is not known, the results of this study show how important it is to ensure that the drug and excipients comply with pharmacopeial or FDA standards.en_US
dc.description.urihttp://dx.doi.org/10.1021/mp100459y
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.subjectToxic glycolsen_US
dc.subjectsolvateen_US
dc.subjectrifampinen_US
dc.subjectcontaminated solventsen_US
dc.titleCrystallization of Toxic Glycol Solvates of Rifampin from Glycerin and Propylene Glycol Contaminated with Ethylene Glycol or Diethylene Glycolen_US
dc.typeArticleen_US


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