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Transdermal drug delivery enhancement by compounds of natural origin

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dc.contributor.author Fox, Lizelle Trifena
dc.contributor.author Gerber, Minja
dc.contributor.author Hamman, Josias Hendrik
dc.contributor.author Du Plessis, Jeanetta
dc.date.accessioned 2012-11-12T08:48:31Z
dc.date.available 2012-11-12T08:48:31Z
dc.date.issued 2011
dc.identifier.citation Fox, L.T. et al. 2011. Transdermal drug delivery enhancement by compounds of natural origin. Molecules, 16(12):10507-10540. [http://www.mdpi.com/journal/molecules] en_US
dc.identifier.issn 1431-5157
dc.identifier.issn 1420-3049 (Online)
dc.identifier.uri http://hdl.handle.net/10394/7746
dc.description.abstract The transdermal route of administration offers an alternative pathway for systemic drug delivery with numerous advantages over conventional routes. Regrettably, the stratum corneum forms a formidable barrier that hinders the percutaneous penetration of most drugs, offering an important protection mechanism to the organism against entrance of possible dangerous exogenous molecules. Different types of penetration enhancers have shown the potential to reversibly overcome this barrier to provide effective delivery of drugs across the skin. Although certain chemical and physical skin penetration enhancers are already employed by the pharmaceutical industry in commercially available transdermal products, some skin penetration enhancers are associated with irritating and toxic effects. This emphasizes the need for the discovery of new, safe and effective skin penetration enhancers. Penetration enhancers from natural origin have become popular as they offer several benefits over their synthetic counterparts such as sustainable mass production from a renewable resource and lower cost depending on the type of extraction used. The aim of this article is to give a comprehensive summary of the results from scientific research conducted on skin penetration enhancers of natural origin. The discussions on these natural penetration enhancers have been organized into the following chemical classes: essential oils, terpenes, fatty acids and polysaccharides. en_US
dc.description.uri http://dx.doi.org/10.3390/molecules161210507
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.subject Natural en_US
dc.subject penetration enhancer en_US
dc.subject essential oils en_US
dc.subject terpene en_US
dc.subject polysaccharide en_US
dc.title Transdermal drug delivery enhancement by compounds of natural origin en_US
dc.type Article en_US


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