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dc.contributor.authorBergh, Jacobus Johannes
dc.contributor.authorHarvey, Brian Herbert
dc.contributor.authorHeyer, Nicolette
dc.contributor.authorMienie, Lodewyk Jacobus
dc.contributor.authorTerre'blanche, Gisella
dc.contributor.authorVan der Schyf, Cornelius J.
dc.date.accessioned2012-11-14T06:53:10Z
dc.date.available2012-11-14T06:53:10Z
dc.date.issued2011
dc.identifier.citationTerre'blanche, G. et al. 2011. The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: influence of dose escalation/reduction over time. Neurotoxicity research, 20(1):97-101. [http://link.springer.com/journal/12640]en_US
dc.identifier.issn1029-8428
dc.identifier.issn1476-3524 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/7755
dc.description.abstractExposure to the industrial solvent, styrene, induces locomotor and cognitive dysfunction in rats, and parkinsonian-like manifestations in man. The antipsychotic, haloperidol (HP), well known to induce striatal toxicity in man and animals, and styrene share a common metabolic pathway yielding p-fluoro phenylglyoxylic acid and phenylglyoxylic acid (PGA), respectively. Using an exposure period of 30 days and the vacous chewing movement (VCM) model as an expression of striatal-motor toxicity, we found that incremental PGA dosing (220–400 mg/kg) significantly increased VCMs up to day 25, but decreased to control levels shortly after reaching maximum dose. However, a diminishing dose of PGA (400–200 mg/kg) did not evoke an immediate worsening of VCMs but precipitated a significant increase in VCMs following dosage reduction to 200 mg/kg on day 22. PGA exposure, therefore, compromises striatal-motor function that is especially sensitive to changes in exposure dose. Longer alternating dose exposure studies are needed to establish whether motor dysfunction is progressive in severity or longevity. These findings are of significance for the environmental toxicology of styrene in the chemical industry.en_US
dc.description.urihttp://dx.doi.org/10.1007/s12640-010-9222-y
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectStyrene phenylglyoxylic aciden_US
dc.subjecthaloperidolen_US
dc.subjectvacuous chewing movementsen_US
dc.subjectstriatumen_US
dc.subjectdose variationen_US
dc.titleThe styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: influence of dose escalation/reduction over timeen_US
dc.typeArticleen_US


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