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The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: influence of dose escalation/reduction over time

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dc.contributor.author Bergh, Jacobus Johannes
dc.contributor.author Harvey, Brian Herbert
dc.contributor.author Heyer, Nicolette
dc.contributor.author Mienie, Lodewyk Jacobus
dc.contributor.author Terre'blanche, Gisella
dc.contributor.author Van der Schyf, Cornelius J.
dc.date.accessioned 2012-11-14T06:53:10Z
dc.date.available 2012-11-14T06:53:10Z
dc.date.issued 2011
dc.identifier.citation Terre'blanche, G. et al. 2011. The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: influence of dose escalation/reduction over time. Neurotoxicity research, 20(1):97-101. [http://link.springer.com/journal/12640] en_US
dc.identifier.issn 1029-8428
dc.identifier.issn 1476-3524 (Online)
dc.identifier.uri http://hdl.handle.net/10394/7755
dc.description.abstract Exposure to the industrial solvent, styrene, induces locomotor and cognitive dysfunction in rats, and parkinsonian-like manifestations in man. The antipsychotic, haloperidol (HP), well known to induce striatal toxicity in man and animals, and styrene share a common metabolic pathway yielding p-fluoro phenylglyoxylic acid and phenylglyoxylic acid (PGA), respectively. Using an exposure period of 30 days and the vacous chewing movement (VCM) model as an expression of striatal-motor toxicity, we found that incremental PGA dosing (220–400 mg/kg) significantly increased VCMs up to day 25, but decreased to control levels shortly after reaching maximum dose. However, a diminishing dose of PGA (400–200 mg/kg) did not evoke an immediate worsening of VCMs but precipitated a significant increase in VCMs following dosage reduction to 200 mg/kg on day 22. PGA exposure, therefore, compromises striatal-motor function that is especially sensitive to changes in exposure dose. Longer alternating dose exposure studies are needed to establish whether motor dysfunction is progressive in severity or longevity. These findings are of significance for the environmental toxicology of styrene in the chemical industry. en_US
dc.description.uri http://dx.doi.org/10.1007/s12640-010-9222-y
dc.language.iso en en_US
dc.publisher Springer en_US
dc.subject Styrene phenylglyoxylic acid en_US
dc.subject haloperidol en_US
dc.subject vacuous chewing movements en_US
dc.subject striatum en_US
dc.subject dose variation en_US
dc.title The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: influence of dose escalation/reduction over time en_US
dc.type Article en_US


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