dc.contributor.author | Huisman, Hugo Willem | |
dc.contributor.author | Kruger, Iolanthe Marike | |
dc.contributor.author | Schutte, Aletta Elisabeth | |
dc.date.accessioned | 2012-12-04T06:35:14Z | |
dc.date.available | 2012-12-04T06:35:14Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Kruger, I.M. et al. 2011. The relationship between adiponectin, ageing and renal function in a bi-ethnic sample. Regulatory peptides, 169(1-30:58-63. [http://www.journals.elsevier.com/regulatory-peptides/] | en_US |
dc.identifier.issn | 0167-0115 | |
dc.identifier.issn | 1873-1686 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/7814 | |
dc.identifier.uri | http://dx.doi.org/10.1016/j.regpep.2011.04.003 | |
dc.description.abstract | Ageing is associated with elevated adiponectin levels. Our aim was to assess whether age-related increase in adiponectin is associated with a decrease in renal function. The study comprised African (N = 277) and Caucasian (N = 326) men and women. Adiponectin levels, estimated creatinine clearance rate and obesity indices were determined. African men revealed significantly higher adiponectin levels compared to Caucasian men (p < 0.01), reflecting the lower adiposity levels of the African men. No difference in obesity measures (p = 0.92) and adiponectin levels (p = 0.27) was observed between African and Caucasian women. A significant increase in adiponectin levels with ageing was observed in both African men and women (p < 0.01). To the contrary, progressive ageing seems not to be significantly related to elevated adiponectin levels within Caucasians. Renal impairment decreased significantly within all of the groups (p < 0.01). Single regression analyses performed in all specified groups revealed significant associations between adiponectin and estimated creatinine clearance, however a multiple regression model revealed that insulin resistance had the strongest association with adiponectin within all the groups. In conclusion, age-related rise in adiponectin levels observed in Africans may not be due to renal impairment. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Adiponectin | en_US |
dc.subject | renal function | en_US |
dc.subject | ageing | en_US |
dc.subject | Africans | en_US |
dc.title | The relationship between adiponectin, ageing and renal function in a bi-ethnic sample | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 10062718 - Huisman, Hugo Willem | |
dc.contributor.researchID | 10922180 - Schutte, Aletta Elisabeth | |