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dc.contributor.authorKruger, R.
dc.contributor.authorSchutte, R.
dc.contributor.authorHuisman, H.W.
dc.contributor.authorSchutte, A.E.
dc.contributor.authorArgraves, W.S.
dc.contributor.authorRasmussen, L.
dc.contributor.authorOlsen, M.D.
dc.contributor.authorKruger, R.
dc.contributor.authorSchutte, R.
dc.contributor.authorHuisman, H.W.
dc.contributor.authorSchutte, A.E.
dc.contributor.authorArgraves, W.S.
dc.contributor.authorRasmussen, L.
dc.contributor.authorOlsen, M.D.
dc.date.accessioned2013-11-14T07:18:26Z
dc.date.available2013-11-14T07:18:26Z
dc.date.issued2012
dc.identifier.citationKruger, R. et al. 2012. NT-proBNP is associated with fibulin-1 in Africans: The SAfrEIC study. Atherosclerosis, 222(1):216-221. [http://www.elsevier.com/locate/atherosclerosis]en_US
dc.identifier.issn1567-5688
dc.identifier.issn1878-5050 (O)
dc.identifier.urihttp://hdl.handle.net/10394/9489
dc.description.abstractObjectives The N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is involved in the regulation of volume load and secreted when systemic cardiac overload occurs. Fibulin-1 on the other hand is a component of many extracellular matrix proteins including those present in atherosclerotic lesions, expressed in elastin-containing fibres of blood vessels, and also in the heart. Due to an alarming prevalence of hypertensive heart disease in black South Africans, we investigated the associations of NT-proBNP with fibulin-1 and markers of arterial stiffness in Africans and Caucasians. Methods We included 231 Africans and 238 Caucasians from South Africa aged 22–77 years. Serum NT-proBNP and fibulin-1 levels were determined, and arterial compliance and pulse wave velocity were measured. Results Africans had significantly higher blood pressure and NT-proBNP levels than Caucasians and African men had higher fibulin-1 levels than Caucasian men. In single regression analysis, NT-proBNP was significantly associated with fibulin-1 in African men and Caucasian women. NT-proBNP correlated negatively with arterial compliance in all groups except Caucasian women. After partial adjustments, the association between NT-proBNP and fibulin-1 strengthened in African men only. After full adjustment in multiple regression analysis, the association of NT-proBNP with fibulin-1 was confirmed in African men (R2 = 0.41; β = 0.26; p < 0.01) and also in younger women (R2 = 0.34; β = 0.251; p = 0.012). Conclusions Only Africans indicated a significant independent association between NT-proBNP and fibulin-1, suggesting that cardiovascular alterations are already present in this relatively young African population as opposed to Caucasians.en_US
dc.description.urihttp://dx.doi.org/10.1016/j.atherosclerosis.2012.01.045
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectNT-proBNPen_US
dc.subjectFibulin-1en_US
dc.subjectCardiovascular functionen_US
dc.subjectArterial stiffnessen_US
dc.subjectExtracellular matrix remodellingen_US
dc.titleNT-proBNP is associated with fibulin-1 in Africans: The SAfrEIC studyen_US
dc.typeArticleen_US
dc.contributor.researchID10062718 - Huisman, Hugo Willem
dc.contributor.researchID20035632 - Kruger, Ruan
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID12201405 - Schutte, Rudolph


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