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dc.contributor.authorGriffiths, Madelein E.
dc.contributor.authorMalan, Leoné
dc.contributor.authorVan Rooyen, Johannes M.
dc.contributor.authorKoekemoer, Gerhard
dc.contributor.authorVorster, Chris B.
dc.date.accessioned2014-01-13T07:06:53Z
dc.date.available2014-01-13T07:06:53Z
dc.date.issued2012
dc.identifier.citationGriffiths, M.E. et al. 2012. Silent ischemia is associated with subclinical atherosclerosis in African males: the sympathetic activity and ambulatory blood pressure in Africans study. Clinical & experimental hypertension, 34(5):363-369. [https://doi.org/10.3109/10641963.2011.649935]en_US
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/9908
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/10641963.2011.649935
dc.identifier.urihttps://doi.org/10.3109/10641963.2011.649935
dc.description.abstractSilent myocardial ischemia is a predictor of subclinical atherosclerosis driven by increased cardiovascular risk markers, although still unknown in Africans. The aim of this study was to assess if cardiovascular risk markers will be associated with subclinical atherosclerosis. African men were stratified into (i) 24-hour silent ischemia (SI, n = 38) and (ii) without (nSI, n = 40) groups. Ambulatory blood pressure (BP), SI, 12-lead resting electrocardiogram, ultrasound carotid intima-media thickness (CIMT) measurements, and fasting blood samples were obtained. Above-normal cardiovascular risk markers, that is, glucose level, heart rate, BP, and CIMT, were evident in men with SI. Hypertension prevalence was 89% in the African SI men as opposed to 64% in the nSI men. Regression analyses revealed that only SI events in SI men explained 35% (95% confidence interval [CI]: 0.22;0.52) of the variance in CIMT, while in all African men it explained 29% (95% CI: 0.19;0.39). In conclusion, SI was associated with structural vascular disease in African men. This could imply that SI is not necessarily driven by hypertension in African men but through other possible mechanisms such as increased sympathetic nervous system activity.en_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.subjectSilent ischemiaen_US
dc.subjectAmbulatory blood pressureen_US
dc.subjectSubclinical atherosclerosisen_US
dc.subjectAfricansen_US
dc.subjectStrokeen_US
dc.titleSilent ischemia is associated with subclinical atherosclerosis in African males: the sympathetic activity and ambulatory blood pressure in Africans studyen_US
dc.typeArticleen_US
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID10059539 - Van Rooyen, Johannes Marthinus
dc.contributor.researchID22713077 - Vorster, Barend Christiaan
dc.contributor.researchID10096353 - Koekemoer, Gerhard
dc.contributor.researchID20045336 - Griffiths, Madelein Elizabeth


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