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Monoamine oxidase inhibition by novel quinolinones
(2014)Parkinson’s disease (PD) is an age-related neurodegenerative disorder. The degeneration of the neurons of the substantia nigra in the midbrain leads to the loss of dopamine from the striatum, which is responsible for the ... -
Monoamine oxidase inhibition by selected anilide derivatives
(Elsevier, 2011)A series of anilide derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The most potent inhibitors among the derivatives that were initially evaluated were ... -
Monoamine oxidase inhibition by selected dye compounds
(Wiley, 2019)Monoamine oxidase (MAO) is an important drug target as the MAO isoforms play key roles in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as in neuropsychiatric diseases such as ... -
Monoamine oxidase inhibition properties of 2,1‑benzisoxazole derivatives
(Springer, 2023)onoamine oxidase (MAO) are favoenzymes that metabolize neurotransmitter, dietary and xenobiotic amines to their corre sponding aldehydes with the production of hydrogen peroxide. Two isoforms, MAO-A and MAO-B, are expressed ... -
The monoamine oxidase inhibition properties of C6- and N1-substituted 3-methyl-3,4-dihydroquinazolin-2(1H)-one derivatives
(Springer, 2020)Quinazolinone compounds are of interest in medicinal chemistry since they display a wide range of biological properties. In the present study, a series of C6- and N1-substituted 3-methyl-3,4-dihydroquinazolin-2(1H)-one ... -
The monoamine oxidase inhibition properties of C6-mono- and N3/C6-disubstituted derivatives of 4(3H)-quinazolinone
(Elsevier, 2019)Parkinson’s disease is characterised by the death of the nigrostriatal neurons and depletion of striatal dopamine. The standard symptomatic therapy consists of dopamine replacement with l-dopa, the metabolic precursor of ... -
The monoamine oxidase inhibition properties of caffeine analogues containing saturated C–8 substituents
(North-West University, 2010)Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized pathologically by a marked loss of dopaminergic nigrostriatal neurons and clinically by disabling movement disorders. PD can be treated ... -
Monoamine oxidase inhibition properties of quinolinone analogues
(North-West University (South Africa), Potchefstroom Campus, 2016)Parkinson's disease (PD) is an age-related neurodegenerative disorder characterised by selective loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) of the brain. This leads to the loss of dopamine ... -
The monoamine oxidase inhibition properties of selected structural analogues of methylene blue
(Elsevier, 2017)The thionine dye, methylene blue (MB), is a potent inhibitor of monoamine oxidase (MAO) A, a property that may, at least in part, mediate its antidepressant effects in humans and animals. The central inhibition of MAO-A ... -
Monoamine oxidase inhibitory activities of heterocyclic chalcones
(2013)Parkinson’s disease is the second most common age-related neurodegenerative disease after Alzheimer’s disease. The characteristic pathological feature of Parkinson’s disease is the loss of neurons in the substantia nigra ... -
Monoamine oxidase inhibitory activities of heterocyclic chalcones
(Elsevier, 2015)Studies have shown that natural and synthetic chalcones (1,3-diphenyl-2-propen-1-ones) possess monoamine oxidase (MAO) inhibition activities. Of particular importance to the present study is a report that a series of ... -
Monocyte chemoattractant protein-1 and large artery structure and function in young individuals : the African-PREDICT study
(North-West University (South Africa) , Potchefstroom Campus, 2015)Motivation - In sub-Saharan Africa, the burden of cardiovascular diseases (CVD) is increasing at an alarming rate. This may be due to the rapid urbanisation of traditional black populations, leading to lifestyle changes ... -
Monogenean parasites from the stomach of Oreochromis mossambicus from South Africa: two new species of Enterogyrus (Dactylogyridae: Ancyrocephalinae)
(Springer, 2020)The study provides descriptions of two new species of Enterogyrus coexisting in the stomach of the Mozambique tilapia, Oreochromis mossambicus (Peters). Enterogyrus multispiralis n. sp. and Enterogyrus mashegoi n. sp. were ... -
Monomers, polymers and cross-linked membranes for membrane fuel cells and electrolysis
(Electrochemical Society, 2011)This contribution comprises an overview about work in the development of ionomers/ionomer (blend) membranes for fuel cells. The topics include the development of novel sulfonated monomers and homo- and copolymers; the ... -
Monophyly of the species of Hepatozoon (Adeleorina: Hepatozoidae) parasitizing (African) anurans, with the description of three new species from hyperoliid frogs in South Africa
(Cambridge Univ Press, 2018)Haemogregarines (Apicomplexa: Adeleiorina) are a diverse group of haemoparasites reported from almost all vertebrate classes. The most commonly recorded haemogregarines to parasitize anurans are species of Hepatozoon ... -
Monsters of the universe : the build-up of the most massive galaxies / Ilani Loubser
(North-West University (South Africa). Potchefstroom Campus, 2021) -
A Monte Carlo evaluation of the performance of two new tests for symmetry
(Springer, 2017)We propose two new tests for symmetry based on well-known characterisations of symmetric distributions. The performance of the new tests is evaluated and compared to that of other existing tests by means of a Monte Carlo ... -
Monte carlo modelling and dosimetric evaluation of cobalt-60 teletherapy in advanced radiation oncology
(North-West University (South Africa), 2016)Numerous external beam radiotherapy innovations have emerged, and these are biased to linear accelerators. A very few computational studies have been undertaken concerning these in cobalt-60 teletherapy. The influence of ... -
Monte Carlo Simulations of Compton Polarization in Astrophysical Sources
(North-West University (South Africa)North-West University, 2020)The description of many high-energy astrophysical sources relies on the production of relativistic jets that are accompanied by the acceleration of particles up to very high energies, and the production of non-thermal ... -
Monte Carlo studies for the optimisation of the Cherenkov Telescope Array layout
(Elsevier, 2019)The Cherenkov Telescope Array (CTA) is the major next-generation observatory for ground-based very-high-energy gamma-ray astronomy. It will improve the sensitivity of current ground-based instruments by a factor of five ...
