Browsing by Subject "Alzheimer's disease"
Now showing items 1-7 of 7
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Design and synthesis of dual acting carbamate inhibitors of acetylcholinesterase and monoamine oxidase
(North-West University (South Africa) , Potchefstroom Campus, 2017)Alzheimer’s disease (AD), the most common neurodegenerative disorder, affects about 10% of the population over the age of 65 years. The disease is typified by symptoms such as memory loss and impairment in abilities including ... -
The development of simple HPLC methods to separate methylene blue and its metabolites
(North-West University (South Africa), Potchefstroom Campus, 2018)The possible treatment and prevention of Alzheimer’s disease (AD) is one of many clinical applications of methylene blue (MB) that has recently attracted much interest. Due to its ability to interact with various targets, ... -
The development of simple HPLC methods to separate methylene blue and its metabolites
(North-West University, 2018)The possible treatment and prevention of Alzheimer’s disease (AD) is one of many clinical applications of methylene blue (MB) that has recently attracted much interest. Due to its ability to interact with various targets, ... -
The interactions of azure B, a metabolite of methylene blue, with 2 acetylcholinesterase and butyrylcholinesterase
(Elsevier, 2014)Methylene blue(MB) is reported to possess diverse pharmacological actions and is attracting increasing attention for the treatment of neurodegenerative disorders such as Alzheimer's disease. Among the pharmacological actions ... -
MutPred mutational load analysis shows mildly deleterious mitochondrial DNA variants are not more prevalent in Alzheimer's patients, but may be under-represented in healthy older individuals
(Elsevier, 2017)Mitochondrial DNA (mtDNA) association studies have been conducted for over a decade using the haplogroup (lineage) association method, but this frequently produces conflicting results. Here we analyzed complete mtDNA ... -
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease
(Elsevier, 2017)A series of 7-substituted coumarin derivatives were designed and synthesised to display ChE and MAO-B inhibitory activity. The compounds consisted out of a coumarin structure (MAO-B inhibitor) and benzyl-, piperidine-, ... -
The synthesis and evaluation of imidazopyridines as adenosine receptor antagonists
(North-West University (South Africa) , Potchefstroom Campus, 2017)Alzheimer’s disease (AD) is the most common occurring neurodegenerative disorder worldwide and includes deficiencies in memory and cognitive impairment. Both the hippocampus and cortex are important neuronal areas in the ...