Browsing by Subject "Caco-2"
Now showing items 1-10 of 11
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Absorptive and secretory transport of selected artemisinin derivatives across Caco-2 cell monolayers
(Bentham Science, 2018)Background: Malaria continues to be a major health concern and affects more than 200 million people a year. Drugs currently used for treatment of malaria are increasingly rendered ineffectual by the ongoing emergence of ... -
Drug absorption enhancement capacities and mechanisms of action of Aloe vera gel materials
(North-West University (South Africa), Potchefstroom Campus, 2018)Oral drug delivery is one of the most preferred and user friendly routes of drug administration. Macromolecular drugs (such as peptides and proteins) generally have a poor bioavailability when administered orally. Absorption ... -
Herb-drug pharmacokinetic interactions: transport and metabolism of indinavir in the presence of selected herbal products
(MDPI, 2015)Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions. This study aimed to determine if pharmacokinetic interactions ... -
Impact of selected herbal products on intestinal epithelial permeation and metabolism of indinavir
(2014)Patients on anti-retroviral (ARV) drug treatment are sometimes simultaneously taking other prescribed drugs and/or over-the-counter drugs and/or herbal remedies. Pharmacokinetic drug-drug or herb-drug interactions can occur ... -
In vitro drug permeation enhancement potential of aloe gel materials
(Bentham Science, 2012)Aloe vera gel previously showed the ability to increase the bioavailability of vitamins and to enhance the in vitro transport of a macromolecular drug across intestinal epithelial cell monolayers. The purpose of this study ... -
Intestinal drug absorption enhancement by Aloe vera gel and whole leaf extract: in vitro investigations into the mechanisms of action
(MDPI, 2019)The co-administration of absorption enhancing agents with macromolecular drugs (e.g., protein and peptide drugs) has been identified as a means to improve the oral bioavailability of these drugs. Absorption-enhancing agents ... -
Investigating the absorptive and secretory transport of selected anti-malarial drugs
(North-West University, 2018)Malaria is one of the predominant infectious diseases affecting more than 200 million people a year worldwide. Artemisinin combination therapy (ACT) is currently the frontline treatment against the Plasmodium falciparum ... -
Investigation of the pharmacokinetic interactions between Hypoxis hemerocallidea and indinavir
(North-West University (South Africa) , Potchefstroom Campus, 2016)It has been established that phytochemicals in herbal medicines can result in pharmacokinetic interactions when co-administrated with allopathic drugs. These herb-drug pharmacokinetic interactions may lead to an increase ... -
Permeation of PLGA nanoparticles across different in vitro models
(Bentham Science, 2012)Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance ... -
Pharmacokinetic interactions of Aloe vera gel polysaccharides with indinavir
(North-West University (South Africa) , Potchefstroom Campus, 2015)Aloe vera (L.) Burm.f. (Aloe barbadensis Miller) gel and whole leaf materials have shown the ability to modulate the bioavailability of vitamins and to change the transport of molecules across intestinal epithelia. In this ...