Browsing by Subject "Clofazimine"
Now showing items 1-8 of 8
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Development of a self-emulsifying drug delivery system for optimized topical delivery of clofazimine
(MDPI, 2020)A quality-by-design and characterization approach was followed to ensure development of self-emulsifying drug delivery systems (SEDDSs) destined for topical delivery of the highly lipophilic clofazimine. Solubility and ... -
Development of a topical self-emulsifying drug delivery system for optimised delivery
(North-West University (South-Africa), 2020)In order to achieve successful receptor binding affinity at complex pharmacological targets the majority of drugs are of a lipophilic nature. However, optimisation of drug delivery systems for lipophilic drugs presents ... -
Formulation and topical delivery of liposomes and proliposomes containing clofazimine
(North-West University (South Africa) , Potchefstroom Campus, 2016)The continual market increase in the transdermal and topical delivery of drugs makes cutaneous drug delivery exploration all the more attractive for scientists (Larraῆeta et al., 2016:62). The key in the delivery of drugs ... -
Formulation of natural oil nano-emulsions for the topical delivery of clofazimine, artemisone and decoquinate
(Springer, 2018)Purpose The aim of this study was to formulate nano-emulsions comprising natural oils and the active pharmaceutical ingredients (APIs) clofazimine (CLF), artemisone (ATM) and decoquinate (DQ) in order to determine ... -
Natural oil nano-emulsion dispersions for the topical delivery of clofazimine, artemisone and decoquinate
(North-West University, Potchefstroom Campus, 2018)Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb) (Godreuil et al., 2007:1), manifests as an extra-pulmonary disease in 3.7 to 8.4% of cases, whereas cutaneous tuberculosis (CTB), which is uncommon, ... -
Topical delivery of artemisone, clofazimine and decoquinate encapsulated in vesicles and their in vitro efficacy against Mycobacterium tuberculosis
(Springer, 2019)Vesicles are widely investigated as carrier systems for active pharmaceutical ingredients (APIs). For topical delivery, they are especially effective since they create a “depot-effect” thereby concentrating the APIs in the ... -
Topical delivery of clofazimine from an avocado oil nano-emulsion
(North-West University (South Africa) , Potchefstroom Campus, 2016)The skin is the largest organ of the human body (Finch, 2003:29). The outermost layer of the skin, the stratum corneum, offers a protective barrier that prevents foreign substances from penetrating into the body through ... -
Topical delivery of clofazimine, artemisone and decoquinate utilizing vesicles as carrier system
(North-West University, 2018)Artemisone, clofazimine and decoquinate are part of the MALTBRedox MRC South African University Flagship Projects, which focus on oxidant-redox drug combinations for the treatment of tuberculosis and a few other diseases. ...