Browsing by Subject "Gene expression"
Now showing items 1-10 of 10
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An evaluation of mitochondrial DNA replication and transcription as well as the transcription of selected nuclear genes in in vitro models for OXPHOS deficiencies
(North-West University, 2010)Deficiencies of the oxidative phosphorylation system (OXPHOS) that consists of five enzyme complexes (I-IV) lead to a diversity of cellular consequences. This includes altered Ca2+ homeostasis, reduced ATP production and ... -
Impaired DNA repair and genomic stability in hereditary tyrosinemia type 1
(Elsevier, 2012)The autosomal recessive disorder, hereditary tyrosinemia type 1 (HT1), is caused by a defective fumarylacetoacetate hydrolase enzyme. Consequently intermediate metabolites such as fumarylacetoacetate, succinylacetone and ... -
Investigating the adaptive mitochondrial shuttles and metabolic reprogramming of transporters in complex I (Ndufs4) knockout mice
(North-West University (South Africa), 2022)Mitochondrial disease is one of the most prevalent inherited paediatric disorders among children, with a prevalence of 1 in 5000 children. Leigh syndrome is the result of a Complex I (CI) deficiency and disrupts the redox ... -
Iron and a mixture of DHA and EPA supplementation, alone and in combination, affect bioactive lipid signalling and morbidity of iron deficient South African school children in a two-by-two randomised controlled trial
(Elsevier Sci Ltd, 2016)We recently reported that iron supplementation increased respiratory morbidity in iron deficient South African children. This increase, however, was attenuated when iron was provided in combination with a mixture of DHA/EPA. ... -
Mitochondrial DNA replication and OXPHOS gene transcription show varied responsiveness to Rieske protein knockdown in 143B cells
(Elsevier, 2011)Genetic, biochemical and phenotypic diversity is a hallmark of OXPHOS deficiencies. Among the responses frequently reported for these deficiencies is differential expression of several genes involved in mitochondrial ... -
Oxidative stress biomarkers in the Mediterranean pond turtle (Mauremys leprosa) reveal contrasted aquatic environments in Southern France
(Elsevier, 2017)Increasing anthropogenic activities, like agricultural practices, constitute the main causes of the loss of water quality and disruption of freshwater ecosystems. High concentrations of pesticides, as shown under experimental ... -
Oxidative stress induced by glyphosate-based herbicide on freshwater turtles
(SETAC, 2017)Freshwater ecosystems face very strong anthropogenic pressures, among which overexploitation, habitat degradation, flow modification, species invasion, and water pollution lead to growing threats on biodiversity. Urbanization ... -
OXPHOS gene expression and control in mitochondrial disorders
(Elsevier, 2009)The cellular consequences of deficiencies of the mitochondrial OXPHOS system include a variety of direct and secondary changes in metabolite homeostasis, such as ROS, Ca2+, ADP/ATP, and NAD/NADH. The adaptive responses to ... -
A single dose of vortioxetine, but not ketamine or fluoxetine, increases plasticity-related gene expression in the rat frontal cortex
(Elsevier, 2016)Ketamine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist that has been shown to induce a rapid antidepressant effect in treatment-resistant patients. Vortioxetine is a multimodal-acting antidepressant ... -
A study of the early DNA methylation events in oxidative stressed cultured mammalian cells
(North-West University, 2012)Cells are continuously exposed to reactive oxygen species (ROS) causing oxidative stress. Cells can withstand and counteract ROS using defence mechanisms which range from free radical scavengers, antioxidant enzymes and ...