Browsing by Subject "LC-MS/MS"
Now showing items 1-9 of 9
-
An analytical method to investigate the estrogen metabolism in women taking combined oral contraceptives
(North-West University, 2018)The human body is exposed to numerous (endogenous and exogenous) toxins daily. The body has a protective mechanism to help detoxify certain toxins, through biotransformation processes. However, when exposure exceeds the ... -
Behavioural, neurochemical, inflammatory and mitichondrial markers following social isolation rearing in rats before and after selected deug intervention
(North-West University, 2012)Purpose: Schizophrenia is a progressive degenerative illness that has been causally linked to mitochondrial dysfunction, oxidative stress and a pro-inflammatory state. Social isolation rearing (SIR) in rats models the ... -
Data on the optimisation of a solid phase extraction method for fractionating estrogen metabolites from small urine volumes
(Elsevier, 2020)Certain estrogen metabolites have been implicated in the pathophysiology of breast cancer. Moreover, the estrogen metabolite profiles of healthy women and those with (a high risk of) breast cancer differ significantly. The ... -
Development and validation of an LC-MS/MS method for the quantification of goserelin in a Pheroid (R) formulation, in simulated intestinal fluid
(Elsevier, 2020)The purpose of this reported study was to develop and validate an LC-MS/MS method for the quantification of goserelin in a Pheroid (R) formulation simulated intestinal fluid. Biopharmaceuticals are formulated in drug ... -
Development and validation of LC-ESI-MS/MS methods for quantification of 27 free and conjugated estrogen-related metabolites
(Elsevier, 2020)An imbalance in the estrogen metabolism has been associated with an increased risk of breast cancer development. Evaluation of the estrogen biotransformation capacity requires monitoring of various estrogen metabolites. ... -
Development of a multiple application LC-MS/MS method for targeted metabolic profiling of biological matrices
(North-West University, 2018)Metabolomics is a growing field and a valuable instrument for the identification of dysregulation in the metabolome of a biological system. Different approaches and analytical platforms are available for metabolomics based ... -
The influence of 17-β-estradiol on bioenergetic and estrogen metabolism in macrophages
(North-West University (South Africa), 2023)Breast cancer is a multifactorial disease influenced by a variety of factors in the tumour microenvironment (TME), including hormones such as estrogen, and immune cells such as macrophages. Imbalances in estrogen metabolism ... -
Occurrence and variation of Fusarium free and masked mycotoxins in maize from agriculture regions of South Africa
(North-West University (South Africa), 2019)In the past years, it has become very clear that in mycotoxin-contaminated foodstuffs, many structurally related compounds generated from plant metabolism or during food processing can coexist with the native mycotoxins. ... -
Quantification of coenzymeQ10 in South African pediatric patients with electron transport chain deficiencies
(North-West University (South Africa), Potchefstroom Campus, 2015)CoenzymeQ10 (CoQ10) is an important component of the mitochondrial electron transport chain (ETC). Co010 deficiency mainly affects children, and patients present with heterogeneous clinical phenotypes. Patients frequently ...