Browsing by Subject "MAO-B"
Now showing items 1-8 of 8
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Benzyloxynitrostyrene analogues: a novel class of selective and highly potent inhibitors of monoamine oxidase B
(Elsevier, 2017)This study examines a series of novel 3-benzyloxy-β-nitrostyrene analogues as a novel class of inhibitors of the monoamine oxidase (MAO) enzymes. MAO inhibitors are considered useful for the treatment of depression and ... -
Inhibition of monoamine oxidase by phthalide analogues
(Elsevier, 2013)Based on recent reports that the small molecules, isatin and phthalimide, are suitable scaffolds for the design of high potency monoamine oxidase (MAO) inhibitors, the present study examines the MAO inhibitory properties ... -
Selected chromone derivatives as inhibitors of monoamine oxidase
(Elsevier, 2012)A previous study has shown that a series of C6-benzyloxy substituted chromones exhibit high binding affinities for human monoamine oxidase (MAO) B. In an attempt to discover additional chromones with potent and selective ... -
Selected furanochalcones as inhibitors of monoamine oxidase
(Elsevier, 2013)The validity of the chalcone scaffold for the design of inhibitors of monoamine oxidase has previously been illustrated. In a systematic attempt to investigate the effect of heterocyclic substitution on the monoamine ... -
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease
(Elsevier, 2017)A series of 7-substituted coumarin derivatives were designed and synthesised to display ChE and MAO-B inhibitory activity. The compounds consisted out of a coumarin structure (MAO-B inhibitor) and benzyl-, piperidine-, ... -
The synthesis and evaluation of benzosuberone derivatives as inhibitors of monoamine oxidase
(North-West University, Potchefstroom Campus, 2018)Monoamine oxidase (MAO) is responsible for the catabolism of neurotransmitters such as serotonin and dopamine in the central nervous system and peripheral tissues. MAO inhibitors such as selegiline play a vital part in the ... -
Synthesis and evaluation of sesamol derivatives as inhibitors of monoamine oxidase
(2014)Parkinson’s disease is an age-related neurodegenerative disorder. The major symptoms of Parkinson’s disease are closely linked to the pathology of the disease. The main pathology of Parkinson’s disease consists of the ... -
The synthesis and evaluation of tetralone derivatives as inhibitors of monoamine oxidase
(North-West University, Potchefstroom Campus, 2018)Monoamienoksidase (MAO)-inhibeerders word gebruik vir die behandeling van toestande wat veroorsaak word deur verlaagde vlakke van neuro-oordragstowwe soos dopamien, noradrenalien en serotonien. MAO-inhibeerders is aanvanklik ...