Browsing by Subject "Marinobufagenin"
Now showing items 1-8 of 8
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Autonomic activity and its relationship with the endogenous cardiotonic steroid marinobufagenin: the African-PREDICT study
(Taylor & Francis, 2020)Aim: Marinobufagenin (MBG), a cardiotonic steroid and a natriuretic hormone, is elevated in response to high salt diet consumption. In animal models salt intake stimulates adrenocortical MBG secretion via increased angiotensin ... -
The cardiotonic steroid marinobufagenin is a predictor of increased left ventricular mass in obesity: the African-PREDICT study
(MDPI, 2020)The endogenous Na+/K+-ATPase inhibitor, marinobufagenin (MBG), strongly associates with salt intake and a greater left ventricular mass index (LVMi) in humans and was shown to promote cardiac fibrosis and hypertrophy in ... -
Large artery stiffness is associated with marinobufagenin in young adults: the African-PREDICT study
(Wolters Kluwer, 2018)Objectives: The cardiotonic steroid, marinobufagenin (MBG), has been shown to play a physiological natriuretic role in response to salt intake. However, recent studies in clinical and animal models demonstrated possible ... -
Marinobufagenin and its relationship with systolic blood pressure in a young black and white population : the African-PREDICT study
(North-West University (South Africa) , Potchefstroom Campus, 2016)Motivation: Hypertension remains one of the foremost causes of cardiovascular morbidity and mortality in sub-Saharan Africa. Importantly, the prevalence of hypertension within black and white populations has been ascribed ... -
Marinobufagenin and left ventricular mass in young adults: the African-PREDICT study
(Sage, 2018)Background The endogenous steroidal inhibitor of sodium–potassium-dependent adenosine triphosphate and natriuretic hormone, marinobufagenin, plays a physiological role in ionic homeostasis. Animal models suggest that ... -
Marinobufagenin and markers of early cardiovascular risk in a young black and white population: The African-PREDICT study
(North-West University (South-Africa). Potchefstroom Campus, 2019)There have been many arguments about the harmful effect of increased or low salt intake and its concurrent role in cardiovascular health. While an overwhelming amount of research has focused on the relationship between ... -
Microvascular function in non-dippers: potential involvement of the salt sensitivity biomarker, marinobufagenin-the African-PREDICT study
(Wiley, 2020)Suppressed nighttime blood pressure dipping is associated with salt sensitivity and may increase the hemodynamic load on the microvasculature. The mechanism remains unknown whereby salt sensitivity may increase the ... -
The Na+K+-ATPase inhibitor marinobufagenin and early cardiovascular risk in humans: a review of recent evidence
(Springer, 2019)Purpose of Review This review synthesizes recent findings in humans pertaining to the relationships between marinobufagenin (MBG), a steroidal Na+/K+-ATPase inhibitor and salt-sensitivity biomarker, and early cardiovascular ...