Browsing by Subject "Mitochondria"
Now showing items 1-10 of 18
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Analysis of metallothionein gene expression in oxidative stress related disorders
(North-West University, 2004)Increased reactive oxygen species (ROS) have been reported to be at the centre of various diseases. Although several reports have implicated elevated levels of ROS in the pathogenesis of diabetes mellitus, the early ... -
Co-formulation and therapeutic evaluation of bioactive plant compounds in Pheroid®
(North-West University (South Africa), 2020)Cancer is a global health burden; of which lung cancer is the most frequently diagnosed type and has the highest mortality. The survival profile of lung cancer patients at all stages is dismal despite the availability of ... -
A critical role of mitochondria in BDNF-associated synaptic plasticity after one-week vortioxetine treatment
(Oxford Univ Press, 2018)Background Preclinical studies have indicated that antidepressant effect of vortioxetine involves increased synaptic plasticity and promotion of spine maturation. Mitochondria dysfunction may contribute to the pathophysiological ... -
An evaluation of mitochondrial DNA replication and transcription as well as the transcription of selected nuclear genes in in vitro models for OXPHOS deficiencies
(North-West University, 2010)Deficiencies of the oxidative phosphorylation system (OXPHOS) that consists of five enzyme complexes (I-IV) lead to a diversity of cellular consequences. This includes altered Ca2+ homeostasis, reduced ATP production and ... -
Haplogroup context is less important in the penetrance of mitochondrial DNA complex I mutations compared to mt-tRNA mutations
(Springer, 2018)Mitochondrial diseases are a highly complex, heterogeneous group of disorders. Mitochondrial DNA variants that are linked to disease can exhibit variable expression and penetrance. This has an implication for mitochondrial ... -
Investigating the adaptive mitochondrial shuttles and metabolic reprogramming of transporters in complex I (Ndufs4) knockout mice
(North-West University (South Africa), 2022)Mitochondrial disease is one of the most prevalent inherited paediatric disorders among children, with a prevalence of 1 in 5000 children. Leigh syndrome is the result of a Complex I (CI) deficiency and disrupts the redox ... -
Investigating the effects of the presence of foreign DNA on DNA methylation and DNA repair events in cultured eukaryotic cells
(Elsevier, 2013)Methylation of DNA in eukaryotic cells, global as well as gene-specific, is affected by endogenous and endogenous factors. In this paper, it is reported that deviations in DNA methylation and expression of genes involved ... -
Metallothionein involvement in mitochondrial function and disease : a metabolomics investigation
(North-West University, 2011)One of the many recorded adaptive responses in respiratory chain complex I deficient cells is the over-expression of the small metal binding proteins, metallothioneins (MTs). The antioxidant properties of MTs putatively ... -
Mitochondria are critical for BDNF-mediated synaptic and vascular plasticity of hippocampus following repeated electroconvulsive seizures
(Oxford Univ Press, 2018)Background Electroconvulsive therapy is a fast-acting and efficient treatment of depression used in the clinic. The underlying mechanism of its therapeutic effect is still unclear. However, recovery of synaptic connections ... -
Mitochondrial DNA copy number is not associated with fatigue status in Primary Sjögren’s Syndrome
(Taylor & Francis, 2018)Background: Primary Sjögren’s syndrome (pSS) is a heterogeneous disease characterized by lymphocytic infiltrates to the exocrine glands, causing sicca symptoms and other manifestations. Fatigue is one of the most prominent ...