Browsing by Subject "Molecular docking"
Now showing items 1-10 of 12
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8-Aryl- and alkyloxycaffeine analogues as inhibitors of monoamine oxidase
(Elsevier, 2011)Recently it was reported that a series of 8-benzyloxycaffeine analogues are potent reversible inhibitors of human monoamine oxidase (MAO) A and B. In an attempt to discover additional C8 oxy substituents of caffeine that ... -
Biochemical and Structural Characterization of the Adenylyl Cyclase Activity of a Fusion Epsin N-terminal Homology Protein from Arabidopsis thaliana
(North-West University (South Africa), 2020)Adenylate cyclases (ACs) are enzymes that are known to produce 3',5'-cyclic adenosine monophosphate (cAMP) from 5'-adenosine triphosphate (ATP) as a result of some associated extracellular stimulations. However, the ... -
Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues
(Elsevier, 2010)Based on recent reports that several (E)-8-styrylcaffeinyl analogues are potent reversible inhibitors of monoamine oxidase B (MAO-B), a series of 8-benzyloxycaffeinyl analogues were synthesized and evaluated as inhibitors ... -
Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives
(Elsevier, 2012)A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and -B. In an attempt to discover additional caffeine derivatives ... -
Inhibition of monoamine oxidase by C5-substituted phthalimide analogues
(Elsevier, 2011)Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B. In general, C5- and C6-substitution of isatin leads to enhanced binding ... -
Inhibition of monoamine oxidase by indole and benzofuran derivatives
(Elsevier, 2010)Monoamine oxidase (MAO) is an important drug target for the treatment of neurological disorders. A series of indole and benzofuran derivatives were synthesised and evaluated as inhibitors of the two MAO isoforms, MAO-A and ... -
Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues
(Elsevier, 2011)Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding to the MAO-B isoform ... -
Inhibition of monoamine oxidase by selected C6-substituted chromone derivatives
(Elsevier, 2012)Chromone has been reported to be a useful scaffold for the design of monoamine oxidase (MAO) inhibitors. In an attempt to discover highly potent MAO inhibitors and to contribute to the known structureeactivity relationships ... -
Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues
(Elsevier, 2010)Based on recent reports that several (E)-8-styrylcaffeinyl analogues are potent reversible inhibitors of monoamine oxidase B (MAO-B), a series of 8-benzyloxycaffeinyl analogues were synthesized and evaluated as inhibitors ... -
Monoamine oxidase inhibition by C4-substituted phthalonitriles
(Elsevier, 2012)It was recently reported that a series of C5-substituted phthalimides are remarkably potent reversible inhibitors of recombinant human monoamine oxidase (MAO) B. Modeling studies suggested that the phthalimide ring forms ...