Browsing by Subject "Multidrug resistance"
Now showing items 1-4 of 4
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Efflux as a mechanism of antimicrobial drug resistance in clinical relevant microorganisms: the role of efflux inhibitors
(Taylor & Francis, 2017)Introduction: Microbial resistance against antibiotics is a serious threat to the effective treatment of infectious diseases. Several mechanisms exist through which microorganisms can develop resistance against antimicrobial ... -
Evaluation of the efficacy of selected anticancer compounds in multidrug resistant cell culture models
(North-West University (South-Africa). Potchefstroom Campus, 2019)Small cell lung cancer (SCLC) has an aggressive disseminating nature and the relapse of cancer patients after initial treatment is common. Acquired multidrug resistance (MDR) can often be attributed to over-expression of ... -
In vitro evaluation of the efficacy of selected medicinal plant extracts against multidrug resistant cancer cells
(North-West University (South-Africa). Potchefstroom Campus, 2019)Cancer is ranked as one of the leading causes of death globally, and a significant number of these diagnosed malignancies are found in lung tissue. Small cell lung cancer (SCLC) is a high grade neuroendocrine cancer, which ... -
Models used to screen for the treatment of multidrug resistant cancer facilitated by transporter-based efflux
(Springer, 2019)Purpose Efflux transporters of the adenosine triphosphate-binding cassette (ABC)-superfamily play an important role in the development of multidrug resistance (multidrug resistant; MDR) in cancer. The overexpression of ...