Browsing by Subject "Neurodegeneration"
Now showing items 1-5 of 5
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Antioxidant properties of Lippia javanica (Burm.f.) Spreng.
(North-West University, 2010)The evolution of aerobic metabolic processes unavoidably led to the production of reactive oxygen species (ROS). ROS have the ability to cause harmful oxidative damage to biomolecules. Increased ROS generation and subsequent ... -
Evaluation of polycyclic amines as modulators of calcium homeostasis in models of neurodegeneration
(North-West University, 2012)Compromised calcium homeostasis in the central nervous system (CNS) is implicated as a major contributor in the pathology of neurodegeneration. Dysregulation of Ca2+ homeostasis initiates downstream Ca2+–dependent events ... -
A metabolomics and biochemical investigation of selected brain regions from Ndufs4 knockout mice
(North-West University (South Africa)North-West University, 2020)Mitochondria, the organelles found throughout the cytoplasm of most eukaryotic cells, have essential functions which have been implicated in the etiology of numerous metabolic and degenerative diseases. The mitochondrial ... -
S-nitrosylation and attenuation of excessive calcium flux by pentacycloundecane derivatives
(Bentham Science, 2012)A novel series of polycyclic amines, containing nitrogen monoxide donating moieties, were synthesised and tested for calcium channel and N-methyl-D-aspartate receptor modulating activity. The synthesised compounds were ... -
Synthesis and biological evaluation of pentacycloundecylamines and triquinylamines as voltage-gated calcium channel blockers
(Wiley, 2016)Preclinical studies for neurodegenerative diseases have shown a multi-targeted approach to be successful in the treatment of these complex disorders with several pathoetiological pathways. Polycyclic compounds, such as ...